Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorZhu, Zhe-
Autor(es): dc.creatorCai, Ting-
Autor(es): dc.creatorFan, Lingyan-
Autor(es): dc.creatorLou, Kehong-
Autor(es): dc.creatorHua, Xin-
Autor(es): dc.creatorHuang, Zuoan-
Autor(es): dc.creatorGao, Guosheng-
Data de aceite: dc.date.accessioned2026-02-09T11:18:52Z-
Data de disponibilização: dc.date.available2026-02-09T11:18:52Z-
Data de envio: dc.date.issued2020-05-29-
Data de envio: dc.date.issued2020-05-29-
Data de envio: dc.date.issued2020-06-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41274-
Fonte completa do material: dc.identifierhttp://www.sciencedirect.com/science/article/pii/S1201971220302575-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1138233-
Descrição: dc.descriptionObjective To explore the clinical value of immune-inflammatory markers to assess the severity of coronavirus disease 2019 (COVID-19). Methods 127 consecutive hospitalized patients with confirmed COVID-19 were enrolled in this study, and classified into non-severe and severe groups. Demographics, symptoms, underlying diseases and laboratory data were collected and assessed for predictive value. Results Of 127 COVID-19 patients, 16 cases (12.60%) were classified into the severe group. High level of interleukin-6 (IL-6), C-reaction protein (CRP) and hypertension were independent risk factors for the severity of COVID-19. The risk model based on IL-6, CRP and hypertension had the highest area under the receiver operator characteristic curve (AUROC). Additionally, the baseline IL-6 was positively correlated with other immune-inflammatory parameters and the dynamic change of IL-6 in the severe cases were parallel to the amelioration of the disease. Conclusion Our study showed that high level of IL-6, CRP and hypertension were independent risk factors for assessing the severity of COVID-19. The risk model established upon IL-6, CRP and hypertension had the highest predictability in this study. Besides, IL-6 played a pivotal role in the severity of COVID-19 and had a potential value for monitoring the process of severe cases.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceInternational Journal of Infectious Diseases-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectImmune-inflammatory parameters-
Palavras-chave: dc.subjectCytokine storm-
Palavras-chave: dc.subjectInterleukin 6 (IL-6)-
Título: dc.titleClinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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