Insight into 2019 novel coronavirus: an updated interim review and lessons from SARS-CoV and MERS-CoV

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Autor(es): dc.creatorXie, Mingxuan-
Autor(es): dc.creatorChen, Qiong-
Data de aceite: dc.date.accessioned2026-02-09T11:18:49Z-
Data de disponibilização: dc.date.available2026-02-09T11:18:49Z-
Data de envio: dc.date.issued2020-04-20-
Data de envio: dc.date.issued2020-04-20-
Data de envio: dc.date.issued2020-04-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40218-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S1201971220302046-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1138212-
Descrição: dc.descriptionBackground The rapid spread of the coronavirus disease 2019 (COVID-19), caused by a zoonotic beta-coronavirus entitled 2019 novel coronavirus (2019-nCoV), has become a global threat. Awareness of the biological features of 2019-nCoV should be updated in time and needs to be comprehensively summarized to help optimize control measures and make therapeutic decisions. Methods Based on recently published literatures, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) infection. Results The genome of 2019-nCoV partially resembled SARS-CoV and MERS-CoV, and indicating a bat origin. The COVID-19 generally had a high reproductive number, a long incubation period, a short serial interval and a low case fatality rate (much higher in patients with comorbidities) than SARS and MERS. Clinical presentation and pathology of COVID-19 greatly resembled SARS and MERS, with less upper respiratory and gastrointestinal symptoms, and more exudative lesions in post-mortems. Potential treatments included remdesivir, chloroquine, tocilizumab, convalescent plasma and vaccine immunization (when possible). Conclusion The initial experience from the current pandemic and lessons from the previous two pandemics can help improve future preparedness plans and combat disease progression.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceInternational Journal of Infectious Diseases-
Palavras-chave: dc.subject2019-nCoV-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus (SARS-CoV)-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectMiddle East respiratory syndrome coronavirus (MERS-CoV)-
Título: dc.titleInsight into 2019 novel coronavirus: an updated interim review and lessons from SARS-CoV and MERS-CoV-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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