Impact of Plasma-Lyte pH 7.4 on acid-base status and hemodynamics in a model of controlled hemorrhagic shock

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorNoritomi, Danilo Teixeira-
Autor(es): dc.creatorPereira, Adriano José-
Autor(es): dc.creatorBugano, Diogo Diniz Gomes-
Autor(es): dc.creatorRehder, Paulo Sergio-
Autor(es): dc.creatorSilva, Eliézer-
Data de aceite: dc.date.accessioned2026-02-09T11:16:53Z-
Data de disponibilização: dc.date.available2026-02-09T11:16:53Z-
Data de envio: dc.date.issued2017-02-17-
Data de envio: dc.date.issued2017-02-17-
Data de envio: dc.date.issued2011-07-13-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/12311-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1137498-
Descrição: dc.descriptionOBJECTIVE: Intravenous infusion of crystalloid solutions is a cornerstone of the treatment of hemorrhagic shock. However, crystalloid solutions can have variable metabolic acid-base effects, perpetuating or even aggravating shock-induced metabolic acidosis. The aim of this study was to compare, in a controlled volume-driven porcine model of hemorrhagic shock, the effects of three different crystalloid solutions on the hemodynamics and acid-base balance. METHODS: Controlled hemorrhagic shock (40% of the total blood volume was removed) was induced in 18 animals, which were then treated with normal saline (0.9% NaCl), Lactated Ringer's Solution or Plasma-Lyte pH 7.4, in a blinded fashion (n = 6 for each group). Using a predefined protocol, the animals received three times the volume of blood removed. RESULTS: The three different crystalloid infusions were equally capable of reversing the hemorrhage-induced low cardiac output and anuria. The Lactated Ringer's Solution and Plasma-Lyte pH 7.4 infusions resulted in an increased standard base excess and a decreased serum chloride level, whereas treatment with normal saline resulted in a decreased standard base excess and an increased serum chloride level. The Plasma-Lyte pH 7.4 infusions did not change the level of the unmeasured anions. CONCLUSION: Although the three tested crystalloid solutions were equally able to attenuate the hemodynamic and tissue perfusion disturbances, only the normal saline induced hyperchloremia and metabolic acidosis.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherUniversidade de São Paulo-
Direitos: dc.rightsacesso aberto-
???dc.source???: dc.sourceClinics-
Palavras-chave: dc.subjectHemorrhagic shock-
Palavras-chave: dc.subjectIsotonic solutions-
Palavras-chave: dc.subjectAcid-base equilibrium-
Palavras-chave: dc.subjectSwine as laboratory animals-
Palavras-chave: dc.subjectChoque hemorrágico-
Palavras-chave: dc.subjectSoluções isotônicas-
Palavras-chave: dc.subjectEquilíbrio ácido-base-
Palavras-chave: dc.subjectSuíno como animal de laboratório-
Título: dc.titleImpact of Plasma-Lyte pH 7.4 on acid-base status and hemodynamics in a model of controlled hemorrhagic shock-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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