P1G10, the proteolytic fraction from vasconcellea cundinamarcensis, stimulates tissue repair after acute exposure to ultraviolet B radiation

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorFreitas, Kátia M.-
Autor(es): dc.creatorSilva, Ana C. Araújo e-
Autor(es): dc.creatorVeloso, Emerson S.-
Autor(es): dc.creatorFerreira, Ênio-
Autor(es): dc.creatorBarcelos, Lucíola S.-
Autor(es): dc.creatorCaliari, Marcelo V.-
Autor(es): dc.creatorSalas, Carlos E.-
Autor(es): dc.creatorLopes, Miriam T. P.-
Data de aceite: dc.date.accessioned2026-02-09T11:15:11Z-
Data de disponibilização: dc.date.available2026-02-09T11:15:11Z-
Data de envio: dc.date.issued2020-04-13-
Data de envio: dc.date.issued2023-06-27-
Data de envio: dc.date.issued2020-04-13-
Data de envio: dc.date.issued2023-06-27-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br//handle/1/57485-
Fonte completa do material: dc.identifierhttps://www.mdpi.com/1422-0067/20/18/4373-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1136896-
Descrição: dc.descriptionBackground: P1G10 is a cysteine proteolytic fraction from Vasconcellea cundinamarcensis latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was suggested an antioxidant role. Methods: We evaluated here the effect of topical treatment with P1G10, in mice lesions induced by UVB. Results: After single exposure to 2.4 J cm−2 UVB, P1G10 reduced erythema, increased cellularity of hypodermis, enhanced MPO activity and IL1β, and inhibited COX2 levels. These results point to an anti-inflammatory effect by P1G10. This fraction displayed antioxidant activity by reversing the depletion of glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and reducing the catalase activity increased by UVB. These changes may be related to a reduction in MDA observed in groups treated with P1G10. P1G10 also inhibited MMP-9, caspase-3 and pkat while increasing p53 levels.-
Idioma: dc.languageen-
Publicador: dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceInternational Journal of Molecular Sciences-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectAnti-inflammatory-
Palavras-chave: dc.subjectC. candamarcensis-
Palavras-chave: dc.subjectErythema-
Palavras-chave: dc.subjectProteolytic-
Palavras-chave: dc.subjectPapain-
Palavras-chave: dc.subjectUltraviolet-
Palavras-chave: dc.subjectHealing-
Título: dc.titleP1G10, the proteolytic fraction from vasconcellea cundinamarcensis, stimulates tissue repair after acute exposure to ultraviolet B radiation-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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