Signal hotspot mutations in SARS-CoV-2 genomes evolve as the virus spreads and actively replicates in different parts of the world

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorWeber, Stefanie-
Autor(es): dc.creatorRamirez, Christina-
Autor(es): dc.creatorDoerfler, Walter-
Data de aceite: dc.date.accessioned2026-02-09T11:15:02Z-
Data de disponibilização: dc.date.available2026-02-09T11:15:02Z-
Data de envio: dc.date.issued2020-10-22-
Data de envio: dc.date.issued2020-10-22-
Data de envio: dc.date.issued2020-10-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/43560-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0168170220310777-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1136841-
Descrição: dc.descriptionSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was first identified in Wuhan, China late in 2019. Nine months later (Sept. 23, 2020), the virus has infected > 31.6 million people around the world and caused > 971.000 (3.07 %) fatalities in 220 countries and territories. Research on the genetics of the SARS-CoV-2 genome, its mutants and their penetrance can aid future defense strategies. By analyzing sequence data deposited between December 2019 and end of May 2020, we have compared nucleotide sequences of 570 SARS-CoV-2 genomes from China, Europe, the US, and India to the sequence of the Wuhan isolate. During worldwide spreading among human populations, at least 10 distinct hotspot mutations had been selected and found in up to > 80 % of viral genomes. Many of these mutations led to amino acid exchanges in replication-relevant viral proteins. Mutations in the SARS-CoV-2 genome would also impinge upon the secondary structure of the viral RNA molecule and its repertoire of interactions with essential cellular and viral proteins. The increasing frequency of SARS-CoV-2 mutation hotspots might select for dangerous viral pathogens. Alternatively, in a 29.900 nucleotide-genome, there might be a limit to the number of mutable and selectable sites which, when exhausted, could prove disadvantageous to viral survival. The speed, at which novel SARS-CoV-2 mutants are selected and dispersed around the world, could pose problems for the development of vaccines and therapeutics.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceVirus Research-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectSequence comparisons between 570 viral genomes to Wuhan isolate-
Palavras-chave: dc.subjectSelection of viral hotspot mutations-
Palavras-chave: dc.subjectImpact on replication-relevant viral proteins-
Título: dc.titleSignal hotspot mutations in SARS-CoV-2 genomes evolve as the virus spreads and actively replicates in different parts of the world-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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