Inactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in mice

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLacerda, Thaís Lourdes Santos-
Autor(es): dc.creatorCardoso, Patrícia Gomes-
Autor(es): dc.creatorAlmeida, LeonardoAugusto de-
Autor(es): dc.creatorCamargo, Ilana Lopes Baratella da Cunha-
Autor(es): dc.creatorAfonso, Daniela Almeida Freitas-
Autor(es): dc.creatorTrant, Cyntia Cardoso-
Autor(es): dc.creatorMacedo, Gilson Costa-
Autor(es): dc.creatorCampos, Eleonora-
Autor(es): dc.creatorCravero, Silvio L.-
Autor(es): dc.creatorSalcedo, Suzana P.-
Autor(es): dc.creatorGorvel, Jean-Pierre-
Autor(es): dc.creatorOliveira, Sérgio Costa-
Data de aceite: dc.date.accessioned2026-02-09T11:13:06Z-
Data de disponibilização: dc.date.available2026-02-09T11:13:06Z-
Data de envio: dc.date.issued2020-04-09-
Data de envio: dc.date.issued2020-04-09-
Data de envio: dc.date.issued2010-08-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/39929-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0264410X10008236-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1136173-
Descrição: dc.descriptionRough mutants of Brucella abortus were generated by disruption of wbkC gene which encodes the formyltransferase enzyme involved in LPS biosynthesis. In bone marrow-derived macrophages the B. abortusΔwbkC mutants were attenuated, could not reach a replicative niche and induced higher levels of IL-12 and TNF-α when compared to parental smooth strains. Additionally, mutants exhibited attenuation in vivo in C57BL/6 and interferon regulatory factor-1 knockout mice. ΔwbkC mutant strains induced lower protective immunity in C56BL/6 than smooth vaccine S19 but similar to rough vaccine RB51. Finally, we demonstrated that Brucella wbkC is critical for LPS biosynthesis and full bacterial virulence.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceVaccine-
Palavras-chave: dc.subjectBrucella abortus-
Palavras-chave: dc.subjectRough strain-
Palavras-chave: dc.subjectLive vaccine-
Título: dc.titleInactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in mice-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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