Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorMatos, Karina Silva-
Autor(es): dc.creatorCunha, Elaine F. F. da-
Autor(es): dc.creatorAbagyan, Ruben-
Autor(es): dc.creatorRamalho, Teodorico C.-
Data de aceite: dc.date.accessioned2026-02-09T11:12:40Z-
Data de disponibilização: dc.date.available2026-02-09T11:12:40Z-
Data de envio: dc.date.issued2018-01-26-
Data de envio: dc.date.issued2018-01-26-
Data de envio: dc.date.issued2014-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/28490-
Fonte completa do material: dc.identifierhttp://www.eurekaselect.com/118968/article-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1136017-
Descrição: dc.descriptionAcetylcholinesterase (AChE) is responsible for hydrolysis of acetylcholine (ACh), a function, which if disrupted, leads to cholinergic syndrome. Carbamates (CB) and organophosphorus compounds (OP) are AChE inhibitors, toxic and capable of causing severe poisoning or death to exposed individuals. The AChE reactivation is considered the main function of the oximes. In case of poisoning by CB, there is no consistent data in the literature for an oxime reactivation mechanism. In this work, we evaluated the affinity and reactivity of oximes with activity already reported against AChE inhibited by the OP chemical warfare agent ciclosarin, with MmAChE and HsAChE active sites inhibited by the CB pesticide carbofuran. Thus, our theoretical data indicate that HLO-7, BI-6 and K005 compounds may be promising reactivators of AChE inhibited by carbofuran.-
Idioma: dc.languageen-
Publicador: dc.publisherBentham Science-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceCombinatorial Chemistry & High Throughput Screening-
Palavras-chave: dc.subjectAcetylcholinesterase-
Palavras-chave: dc.subjectDocking studies-
Palavras-chave: dc.subjectNeurotoxic agents-
Palavras-chave: dc.subjectOximes-
Palavras-chave: dc.subjectAcetilcolinesterase-
Palavras-chave: dc.subjectEstudos de docagem-
Palavras-chave: dc.subjectAgentes neurotóxicos-
Palavras-chave: dc.subjectOximas-
Título: dc.titleComputational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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