Cytotoxic compounds from the marine-derived fungus Aspergillus sp. recovered from the sediments of the Brazilian coast

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSaraiva, Natália N.-
Autor(es): dc.creatorRodrigues, Bárbara S.F.-
Autor(es): dc.creatorJimenez, Paula C.-
Autor(es): dc.creatorGuimarães, Larissa A.-
Autor(es): dc.creatorTorres, Maria C. M.-
Autor(es): dc.creatorRodrigues-Filho, Edson-
Autor(es): dc.creatorPfenning, Ludwig H.-
Autor(es): dc.creatorAbreu, Lucas M.-
Autor(es): dc.creatorMafezoli, Jair-
Autor(es): dc.creatorMattos, Marcos C. de-
Autor(es): dc.creatorCosta-Lotufo, Letícia V.-
Autor(es): dc.creatorOliveira, Maria da Conceição F. de-
Data de aceite: dc.date.accessioned2026-02-09T11:12:02Z-
Data de disponibilização: dc.date.available2026-02-09T11:12:02Z-
Data de envio: dc.date.issued2020-02-20-
Data de envio: dc.date.issued2020-02-20-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/39059-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/full/10.1080/14786419.2014.987772-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1135804-
Descrição: dc.descriptionA fungal strain of Aspergillus sp. (BRF 030) was isolated from the sediments collected in the northeast coast of Brazil, and the cytotoxic activity of its secondary metabolites was investigated against HCT-116 tumour cell line. The cytotoxicity-guided fractionation of the extracts from this fungus cultured in potato-dextrose-sea water for 14 days at room temperature yielded the hetero-spirocyclic γ-lactams pseurotin A (1), pseurotin D (2) and pseurotin FD-838 (7), the alkaloids fumitremorgin C (5), 12,13-dihydroxy fumitremorgin C (6), methylsulochrin (4) and bis(dethio)bis(methylthio)gliotoxin (3). Among them, fumitremorgin C (5) and 12,13-dihydroxy fumitremorgin C (6) were the most active. The cytotoxic activities of the extracts from Aspergillus sp. grown from 7 to 28 days were investigated, and they were associated with the kinetic production of the compounds. The most active extracts (14 and 21 days) were those with the highest relative concentrations of the compounds fumitremorgin C (5) and 12,13-dihydroxy fumitremorgin C (6).-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Online-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceNatural Product Research-
Palavras-chave: dc.subjectMarine-derived fungi-
Palavras-chave: dc.subjectAspergillus sp-
Palavras-chave: dc.subjectCytotoxic activity-
Palavras-chave: dc.subjectDiketopiperazine-
Palavras-chave: dc.subjectPseurotin-
Título: dc.titleCytotoxic compounds from the marine-derived fungus Aspergillus sp. recovered from the sediments of the Brazilian coast-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

Não existem arquivos associados a este item.