Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLei, Changhai-
Autor(es): dc.creatorQian, Kewen-
Autor(es): dc.creatorLi, Tian-
Autor(es): dc.creatorZhang, Sheng-
Autor(es): dc.creatorFu, Wenyan-
Autor(es): dc.creatorDing, Min-
Data de aceite: dc.date.accessioned2026-02-09T11:11:29Z-
Data de disponibilização: dc.date.available2026-02-09T11:11:29Z-
Data de envio: dc.date.issued2020-05-05-
Data de envio: dc.date.issued2020-05-05-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40582-
Fonte completa do material: dc.identifierhttps://www.nature.com/articles/s41467-020-16048-4-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1135624-
Descrição: dc.descriptionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, at the end of 2019, and there are currently no specific antiviral treatments or vaccines available. SARS-CoV-2 has been shown to use the same cell entry receptor as SARS-CoV, angiotensin-converting enzyme 2 (ACE2). In this report, we generate a recombinant protein by connecting the extracellular domain of human ACE2 to the Fc region of the human immunoglobulin IgG1. A fusion protein containing an ACE2 mutant with low catalytic activity is also used in this study. The fusion proteins are then characterized. Both fusion proteins have a high binding affinity for the receptor-binding domains of SARS-CoV and SARS-CoV-2 and exhibit desirable pharmacological properties in mice. Moreover, the fusion proteins neutralize virus pseudotyped with SARS-CoV or SARS-CoV-2 spike proteins in vitro. As these fusion proteins exhibit cross-reactivity against coronaviruses, they have potential applications in the diagnosis, prophylaxis, and treatment of SARS-CoV-2.-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer Nature-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceNature Communications-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectAngiotensin-converting enzyme 2 (ACE2)-
Título: dc.titleNeutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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