Host-viral infection maps reveal signatures of severe COVID-19 patients

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBost, Pierre-
Autor(es): dc.creatorGiladi, Amir-
Autor(es): dc.creatorLiu, Yang-
Autor(es): dc.creatorBendjelal, Yanis-
Autor(es): dc.creatorXu, Gang-
Autor(es): dc.creatorDavid, Eyal-
Autor(es): dc.creatorBlecher-Gonen, Ronnie-
Autor(es): dc.creatorCohen, Merav-
Autor(es): dc.creatorMedaglia, Chiara-
Autor(es): dc.creatorLi, Hanjie-
Autor(es): dc.creatorDeczkowska, Aleksandra-
Autor(es): dc.creatorZhang, Shuye-
Autor(es): dc.creatorSchwikowski, Benno-
Autor(es): dc.creatorZhang, Zheng-
Autor(es): dc.creatorAmit, Ido-
Data de aceite: dc.date.accessioned2026-02-09T11:10:44Z-
Data de disponibilização: dc.date.available2026-02-09T11:10:44Z-
Data de envio: dc.date.issued2020-06-19-
Data de envio: dc.date.issued2020-06-19-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41495-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0092867420305687-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1135368-
Descrição: dc.descriptionViruses are a constant threat to global health as highlighted by the current COVID-19 pandemic. Currently, lack of data underlying how the human host interacts with viruses, including the SARS-CoV-2 virus, limits effective therapeutic intervention. We introduce Viral-Track, a computational method that globally scans unmapped single-cell RNA sequencing (scRNA-seq) data for the presence of viral RNA, enabling transcriptional cell sorting of infected versus bystander cells. We demonstrate the sensitivity and specificity of Viral-Track to systematically detect viruses from multiple models of infection, including hepatitis B virus, in an unsupervised manner. Applying Viral-Track to bronchoalveloar-lavage samples from severe and mild COVID-19 patients reveals a dramatic impact of the virus on the immune system of severe patients compared to mild cases. Viral-Track detects an unexpected co-infection of the human metapneumovirus, present mainly in monocytes perturbed in type-I interferon (IFN)-signaling. Viral-Track provides a robust technology for dissecting the mechanisms of viral-infection and pathology.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
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Palavras-chave: dc.subjectVirus host interactions-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSingle-cell RNA-seq-
Palavras-chave: dc.subjectViral-Track-
Título: dc.titleHost-viral infection maps reveal signatures of severe COVID-19 patients-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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