Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMoura, Rodrigo F. de-
Autor(es): dc.creatorNascimento, Lucas F.-
Autor(es): dc.creatorIgnacio-Souza, Leticia M.-
Autor(es): dc.creatorMorari, Joseane-
Autor(es): dc.creatorRazolli, Daniela S.-
Autor(es): dc.creatorSolon, Carina-
Autor(es): dc.creatorSouza, Gabriela F. P. de-
Autor(es): dc.creatorFestuccia, William T.-
Autor(es): dc.creatorVelloso, Licio A.-
Data de aceite: dc.date.accessioned2026-02-09T11:08:17Z-
Data de disponibilização: dc.date.available2026-02-09T11:08:17Z-
Data de envio: dc.date.issued2021-01-03-
Data de envio: dc.date.issued2021-01-03-
Data de envio: dc.date.issued2016-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/45962-
Fonte completa do material: dc.identifierhttps://www.nature.com/articles/ijo2015188-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1134610-
Descrição: dc.descriptionBackground/Objectives: Stearoyl-CoA desaturase-2 (SCD2) is the main δ9 desaturase expressed in the central nervous system. Because of its potential involvement in controlling whole-body adiposity, we evaluated the expression and function of SCD2 in the hypothalami of mice. Subjects/Methods: Male mice of different strains were used in real-time PCR, immunoblot and metabolic experiments. In addition, antisense oligonucleotides and lentiviral vectors were used to reduce and increase the expression of SCD2 in the hypothalamus. Results: The level of SCD2 in the hypothalamus is similar to other regions of the central nervous system and is ~10-fold higher than in any other region of the body. In the arcuate nucleus, SCD2 is expressed in proopiomelanocortin and neuropeptide-Y neurons. Upon high fat feeding, the level of hypothalamic SCD2 increases. Inhibition of hypothalamic SCD2 as accomplished by two distinct approaches, an antisense oligonucleotide or a short-hairpin RNA delivered by a lentivirus, resulted in reduced body mass gain mostly due to increased energy expenditure and increased spontaneous activity. Increasing hypothalamic SCD2 by a lentivirus approach resulted in no change in body mass and food intake. Conclusions: Thus, SCD2 is highly expressed in the hypothalami of rodents and its knockdown reduces body mass due to increased whole-body energy expenditure.-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer Nature-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceInternational Journal of Obesity-
Palavras-chave: dc.subjectHypothalamus-
Palavras-chave: dc.subjectMolecular neuroscience-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectPhysiology-
Palavras-chave: dc.subjectHipotálamo-
Palavras-chave: dc.subjectNeurociência molecular-
Palavras-chave: dc.subjectObesidade-
Palavras-chave: dc.subjectFisiologia-
Título: dc.titleHypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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