Chemical analysis of Eruca sativa ethanolic extract and its effects on hyperuricaemia.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorTeixeira, Arthur Ferrari-
Autor(es): dc.creatorSouza, Jacqueline de-
Autor(es): dc.creatorDophine, Douglas Daniel-
Autor(es): dc.creatorSouza Filho, José Dias de-
Autor(es): dc.creatorGuimarães, Dênia Antunes Saúde-
Data de aceite: dc.date.accessioned2025-08-21T16:01:20Z-
Data de disponibilização: dc.date.available2025-08-21T16:01:20Z-
Data de envio: dc.date.issued2022-11-03-
Data de envio: dc.date.issued2022-11-03-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/15750-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/molecules27051506-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1030190-
Descrição: dc.descriptionIn vivo assays and chemical analyses were performed on the ethanolic extract from leaves of Eruca sativa. UHPLC-ESI-QTOF analysis confirmed the presence of glucosinolates and flavonol glucosides. The major flavonoid of the ethanolic extract, kaempferol-3,40 -di-O-β-glucoside, was isolated, a HPLC-DAD method developed and validated to quantify its content in the extract. In vivo experiments were carried out on Wistar rats with hyperuricaemia induced by potassium oxonate and uric acid. A hypouricaemic effect was observed in hyperuricaemic Wistar rats treated with ethanolic extract at dose of 125 mg/kg and kaempferol-3,40 -di-O-β-glucoside at dose of 10 mg/kg. The main anti-hyperuricaemic mechanism observed in the extract was uricosuric. Kaempferol-3,40 -di-O-β- glucoside was identified as an important component responsible for the total activity of the ethanolic extract and was considered as a good chemical and biological marker of the ethanolic extract of E. sativa. The obtained results indicated the potential of E. sativa in the treatment of hyperuricaemia and its comorbidities.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: o PDF do artigo.-
Palavras-chave: dc.subjectGlucosinolate-
Palavras-chave: dc.subjectGlucosylated flavonols-
Palavras-chave: dc.subjectRocket-
Palavras-chave: dc.subjectValidation-
Palavras-chave: dc.subjectNMR-
Título: dc.titleChemical analysis of Eruca sativa ethanolic extract and its effects on hyperuricaemia.-
Aparece nas coleções:Repositório Institucional - UFOP

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