Ruthenium(II) complexes with hydroxypyridinecarboxylates : screening potential metallodrugs against Mycobacterium tuberculosis.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBarbosa, Marília Imaculada Frazão-
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorPozzi, Lucas Vinícius dos Santos-
Autor(es): dc.creatorPavan, Fernando Rogério-
Autor(es): dc.creatorLeite, Clarice Queico Fujimura-
Autor(es): dc.creatorEllena, Javier Alcides-
Autor(es): dc.creatorMachado, Sérgio de Paula-
Autor(es): dc.creatorPoelhsitz, Gustavo Von-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Data de aceite: dc.date.accessioned2025-08-21T16:01:00Z-
Data de disponibilização: dc.date.available2025-08-21T16:01:00Z-
Data de envio: dc.date.issued2016-10-05-
Data de envio: dc.date.issued2016-10-05-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7034-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.poly.2014.08.057-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1030056-
Descrição: dc.descriptionThree promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2- OHnic)(dppb)(bipy)]PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the [Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O–O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy)]PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H37Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsO periódico Polyhedron concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3957611410935.-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Palavras-chave: dc.subjectRuthenium(II) complexes-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectMetallodrugs-
Palavras-chave: dc.subjectHydroxypyridinecarboxylates-
Título: dc.titleRuthenium(II) complexes with hydroxypyridinecarboxylates : screening potential metallodrugs against Mycobacterium tuberculosis.-
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