Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?

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Autor(es): dc.creatorSantos, Elda Gonçalves dos-
Autor(es): dc.creatorGonçalves, Reggiani Vilela-
Autor(es): dc.creatorSilva, Thaiany Goulart de Souza e-
Autor(es): dc.creatorMaldonado, Izabel Regina dos Santos Costa-
Autor(es): dc.creatorSantos, Eliziária Cardoso dos-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Autor(es): dc.creatorNatali, Antônio José-
Autor(es): dc.creatorNovaes, Rômulo Dias-
Data de aceite: dc.date.accessioned2025-08-21T16:00:47Z-
Data de disponibilização: dc.date.available2025-08-21T16:00:47Z-
Data de envio: dc.date.issued2020-03-06-
Data de envio: dc.date.issued2020-03-06-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11971-
Fonte completa do material: dc.identifierhttps://www.cambridge.org/core/journals/parasitology/article/could-preinfection-exercise-training-improve-the-efficacy-of-specific-antiparasitic-chemotherapy-for-chagas-disease/AB1B968B3C658DB1A7C99688511182FB-
Fonte completa do material: dc.identifierhttps://doi.org/10.1017/S0031182019000970-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1029959-
Descrição: dc.descriptionConsidering a potential exercise-drug interaction, we investigated whether exercise training could improve the efficacy of specific antiparasitic chemotherapy in a rodent model of Chagas disease. Wistar rats were randomized into five groups: sedentary and uninfected (CT); sedentary and infected (SI); sedentary, infected and treated (SIT); trained and infected (TI); trained, infected and treated (TIT). After 9-weeks running training, the animals were infected with T. cruzi and followed up for 4 weeks, receiving 100 mg kg−1 day−1 benznidazole. No evidence of myocarditis was observed in CT animals. TI animals exhibited reduced parasitemia, myocarditis, and reactive tissue damage compared to SI animals, in addition to increased IFN-γ, IL-4, IL-10, heart non-protein antioxidant (NPA) levels and glutathione-s transferase activity (P < 0.05). The CT, SIT and TIT groups presented similar reductions in parasitemia, cytokines (IFN-γ, TNF-α, IL-4, IL-10, IL-17 and MCP-1), inflammatory infiltrate, oxidative heart damage and antioxidant enzymes activity compared to SI and TI animals, as well as reduced heart microstructural remodeling (P < 0.05). By modulating heart inflammation and redox metabolism, exercise training exerts a protective effect against T. cruzi infection in rats. However, the antiparasitic and cardioprotective effects of benznidazole chemotherapy are more pronounced, determining similar endpoints in sedentary and trained T. cruzi-infected rats.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectCardiovascular pathology-
Palavras-chave: dc.subjectComplementary therapy-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Título: dc.titleCould pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?-
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