Raman spectroscopy with a 1064-nm wavelength laser as a potential molecular tool for prostate cancer diagnosis : a pilot study.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMagalhães, Felipe Lima-
Autor(es): dc.creatorMachado, Alexei Manso Corrêa-
Autor(es): dc.creatorPaulino Junior, Eduardo-
Autor(es): dc.creatorSahoo, Sangram K.-
Autor(es): dc.creatorPaula, Ana Maria de-
Autor(es): dc.creatorGarcia, Aloísio Miguel-
Autor(es): dc.creatorBarman, Ishan-
Autor(es): dc.creatorSoares, Jaqueline dos Santos-
Autor(es): dc.creatorLewer, Marcelo Henrique Mamede-
Data de aceite: dc.date.accessioned2025-08-21T16:00:32Z-
Data de disponibilização: dc.date.available2025-08-21T16:00:32Z-
Data de envio: dc.date.issued2019-06-07-
Data de envio: dc.date.issued2019-06-07-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11477-
Fonte completa do material: dc.identifierhttps://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-23/issue-12/121613/Raman-spectroscopy-with-a-1064-nm-wavelength-laser-as-a/10.1117/1.JBO.23.12.121613.full?SSO=1-
Fonte completa do material: dc.identifierhttps://doi.org/10.1117/1.JBO.23.12.121613-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1029864-
Descrição: dc.descriptionRaman spectroscopy is widely used to investigate the structure and property of the molecules from their vibrational transitions and may allow for the diagnosis of cancer in a fast, objective, and nondestructive manner. This experimental study aims to propose the use of the 1064-nm wavelength laser in a Raman spectroscopy and to evaluate its discrimination capability in prostate cancer diagnosis. Seventy-four spectra from patients who underwent radical prostatectomy were evaluated. The acquired signals were filtered, normalized, and corrected for possible oscillations in the laser intensity and fluorescence effects. Wilcoxon tests revealed significant differences between the benign and malign samples associated with the deformation vibration characteristic of nucleic acids, proteins, and lipids. A classifier based on support vector machines was able to predict the Gleason scores of the samples with 95% of accuracy, opening a perspective for the use of the 1064-nm excitatory wavelength in prostatic cancer diagnosis.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectFluorescence-
Título: dc.titleRaman spectroscopy with a 1064-nm wavelength laser as a potential molecular tool for prostate cancer diagnosis : a pilot study.-
Aparece nas coleções:Repositório Institucional - UFOP

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