Endurance training increases leptin expression in the retroperitoneal adipose tissue of rats fed with a high-sugar diet.

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Autor(es): dc.creatorQueiroz, Karina Barbosa de-
Autor(es): dc.creatorGuimarães, Juliana Bohnen-
Autor(es): dc.creatorCoimbra, Cândido Celso-
Autor(es): dc.creatorRodovalho, Gisele Vieira-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorEvangelista, Elísio Alberto-
Autor(es): dc.creatorCota, Renata Guerra de Sá-
Data de aceite: dc.date.accessioned2025-08-21T15:59:32Z-
Data de disponibilização: dc.date.available2025-08-21T15:59:32Z-
Data de envio: dc.date.issued2017-06-07-
Data de envio: dc.date.issued2017-06-07-
Data de envio: dc.date.issued2014-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7913-
Fonte completa do material: dc.identifierhttp://link.springer.com/article/10.1007%2Fs11745-013-3854-7-
Fonte completa do material: dc.identifierhttps://doi.org/10.1007/s11745-013-3854-7-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1029457-
Descrição: dc.descriptionThe presence of leptin receptors in white adipose tissue (WAT) suggests a type of peripheral control during the development of obesity and other metabolic disorders. Both diet composition and exercise influence serum leptin; however, the effect of their combination on long-term WAT leptin metabolism is unknown. In this study, rats fed with standard or high-sugar diets (HSD) were simultaneously subjected to running training for 4- and 8-week periods, and the retroperitoneal WAT (rWAT) was evaluated for adipocyte cell size, lipid and catecholamine content, Lep, OB-Rb and Ucp2 mRNA transcription levels, and circulating leptin and non-esterified fatty acids (NEFA). The HSD groups displayed a higher adiposity index and rWAT weight, Lep mRNA and protein upregulation, and a period-dependent effect on OB-Rb mRNA expression. Exercise decreased serum leptin and upregulated the OB-Rb mRNA levels. However, in rats fed with an HSD, the increase in OB-Rb mRNA and reduction in catecholamine levels resulted in a high level of adiposity and hyperleptinemia. The combination of training and an HSD decreases the NEFA levels and upregulating the Ucp2 mRNA expression in the 4-week period, while downregulating the Ucp2 mRNA expression in the 8-week period without changing the NEFA levels. Our results suggest that an HSD induces an increase in leptin expression in rWAT, while reducing adipocytes via leptin-mediated lipolysis after an 8-week period. In exercised rats fed an HSD, TAG synthesis and storage overlaps with lipolysis, promoting fat store development and Lep mRNA and plasma protein upregulation in adult rats.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectChronic exercise-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectMetabolism-
Título: dc.titleEndurance training increases leptin expression in the retroperitoneal adipose tissue of rats fed with a high-sugar diet.-
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