Highly conserved CDR3 region in circulating CD4(+) Vβ5(+) T cells may be associated with cytotoxic activity in Chagas disease.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorMenezes, Cristiane Alves da Silva-
Autor(es): dc.creatorSullivan, A. K.-
Autor(es): dc.creatorFalta, M. T.-
Autor(es): dc.creatorMack, D. G.-
Autor(es): dc.creatorFreed, B. M.-
Autor(es): dc.creatorRocha, Manoel Otávio da Costa-
Autor(es): dc.creatorGollob, Kenneth John-
Autor(es): dc.creatorFontenot, A. P.-
Autor(es): dc.creatorDutra, Walderez Ornelas-
Data de aceite: dc.date.accessioned2025-08-21T15:58:26Z-
Data de disponibilização: dc.date.available2025-08-21T15:58:26Z-
Data de envio: dc.date.issued2017-06-05-
Data de envio: dc.date.issued2017-06-05-
Data de envio: dc.date.issued2012-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7880-
Fonte completa do material: dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2012.04608.x/abstract-
Fonte completa do material: dc.identifierhttps://doi.org/10.1111/j.1365-2249.2012.04608.x-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1028975-
Descrição: dc.descriptionHuman infection with Trypanosoma cruzi leads to Chagas disease, which presents as several different clinical conditions ranging from an asymptomatic form to a severe dilated cardiomyopathy. Several studies have demonstrated that T cells play a critical role in the development of cardiac pathology, as well as in immunoregulation during chronic disease. However, the mechanisms that drive protective or pathogenic T cell response are not known.We have shown that CD4+ T cells from chagasic patients preferentially express T cell receptor (TCR) b-chain variable region (Vb) 5. The aim of this work was to determine whether T cells expressing this particular Vb region displayed variable or restricted CDR3 sequences, as an indicator of the nature of the stimulus leading to the activation of these T cells in vivo. Additionally, we aimed to evaluate phenotypic characteristics of these cells that might be associated with pathology. CDR3 junctional region sequencing of Vb5·1 expressing CD4+ T cells revealed the occurrence of a highly homologous CDR3 region with conserved TCR Jb region usage among patients with cardiac, but not indeterminate, Chagas disease. Moreover, correlation analysis indicated that the frequency of CD4+Vb5·1+ cells is associated with granzyme A expression, suggesting that these cells might display cytotoxic function. Together these results provide new insight into T cell recognition of antigens involved in Chagas disease and suggest that these cells may be implicated in the pathogenesis of chagasic cardiomyopathy.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleHighly conserved CDR3 region in circulating CD4(+) Vβ5(+) T cells may be associated with cytotoxic activity in Chagas disease.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.