Versatile grafted microcrystalline cellulose with ionic liquid as new losartan-controlled release material.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSantos, Stefânia Sales de Oliveira-
Autor(es): dc.creatorSinisterra Millán, Ruben Dario-
Autor(es): dc.creatorSpeziali, Marcelo Gomes-
Data de aceite: dc.date.accessioned2025-08-21T15:57:58Z-
Data de disponibilização: dc.date.available2025-08-21T15:57:58Z-
Data de envio: dc.date.issued2020-06-16-
Data de envio: dc.date.issued2020-06-16-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/12353-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0014305719320543-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.eurpolymj.2020.109490-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1028766-
Descrição: dc.descriptionThis paper describes the preparation and characterization of a versatile Losartan-controlled-release material based on a functionalized cellulosic matrix grafted with the ionic liquid, [(MeO)3Sipmim][Cl]: 1–(trimethoxysilylpropyl)–3–methylimidazolium Chloride. A silanized ionic liquid was used as a solvent and a surface modification agent at the same time, allowing higher anionic drug loading capacity. The anionic Losartan drug release kinetics were evaluated as a model. The Losartan release was made using two distinct media, one at pH 7.4 and the other at 3.0 to simulate blood and stomach pH, respectively. Higher Losartan release-rate 88% at blood pH after 1085 min in comparison with 84% at stomach pH, after 330 min was attained. The higher Losartan release profile in acid pH compared with neutral pH could be associated to the hydrolysis of Si-O bond from the ionic liquid, with the acidic medium acting as a catalyst. This cellulosic matrix modified with ionic liquid showed promising for applications over a wide range of pH-controlled-release systems.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectWeibull kinetic model-
Palavras-chave: dc.subjectKorsmeyer – peppas kinetic model-
Palavras-chave: dc.subjectpH-dependent-
Palavras-chave: dc.subjectSilanization-
Palavras-chave: dc.subjectDesorption-
Título: dc.titleVersatile grafted microcrystalline cellulose with ionic liquid as new losartan-controlled release material.-
Aparece nas coleções:Repositório Institucional - UFOP

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