Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorFerreira, Patrícia Maria-
Autor(es): dc.creatorCustódio, Carlos Henrique Xavier-
Autor(es): dc.creatorAlzamora, Andréia Carvalho-
Autor(es): dc.creatorSantos, Robson Augusto Souza dos-
Autor(es): dc.creatorSantos, Maria José Campagnole dos-
Data de aceite: dc.date.accessioned2025-08-21T15:57:19Z-
Data de disponibilização: dc.date.available2025-08-21T15:57:19Z-
Data de envio: dc.date.issued2016-07-25-
Data de envio: dc.date.issued2016-07-25-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/6620-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.npep.2015.09.002-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1028475-
Descrição: dc.descriptionThe central and peripheral renin–angiotensin systems are known for playing a key role in cardiovascular control. In the present study,we evaluated the hemodynamic effects produced by nanoinjections of angiotensin II (Ang II) or angiotensin-(1–7) [Ang-(1–7)] into the rostral ventrolateral medulla (RVLM) of adult male normotensive (Wistar—WT) and spontaneously hypertensive rats (SHR). Animals were anesthetized (urethane 1.2 g/kg) and instrumented for recording blood pressure (BP), heart rate (HR) and blood flow (BF) in the femoral, renal or mesenteric arteries. Afterwards, rats were positioned in a stereotaxic and prepared for nanoinjections (100 nl) of saline (NaCl 0.9%), Ang-(1–7) (40 ng) or Ang II (40 ng) into the RVLM. The vascular resistance (VR)was calculated by ΔMAP/ΔBF ratio. In WT, Ang-(1–7) or Ang II caused equipotent pressor effects that were not accompanied by changes in vascular resistance. However, MAP changes were greater in SHR. This strain also showed a concomitant increase in relative vascular resistance (ΔVR/VRbaseline) of renal (0.31 ± 0.07 and 0.3 ± 0.07 vs. 0.02 ± 0.01; Ang-(1–7), Ang II and Saline, respectively) and mesenteric beds (0.3 ± 0.06 and 0.33 ± 0.04 vs. 0.05 ± 0.02; Ang-(1–7), Ang II and saline, respectively). We conclude that Ang II and Ang-(1–7) at the RVLM control the vascular resistance of renal and mesenteric beds during hypertension.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsO periódico Neuropeptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3894771218803.-
Palavras-chave: dc.subjectRostral ventrolateral medulla-
Palavras-chave: dc.subjectArterial pressure-
Palavras-chave: dc.subjectVascular blood flow-
Palavras-chave: dc.subjectSpontaneously hypertensive rats-
Título: dc.titleDifferential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats.-
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