Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats.

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Autor(es): dc.creatorCustódio, Carlos Henrique Xavier-
Autor(es): dc.creatorMiranda, José Rodolfo Rubini-
Autor(es): dc.creatorYamaguchi, Juliana-
Autor(es): dc.creatorSilveira, Kátia Daniela da-
Autor(es): dc.creatorTeixeira, Mauro Martins-
Autor(es): dc.creatorChianca Júnior, Deoclécio Alves-
Autor(es): dc.creatorSilva, Ana Cristina Simões e-
Autor(es): dc.creatorSantos, Robson Augusto Souza dos-
Autor(es): dc.creatorCamargo, Antônio Carlos Martins de-
Autor(es): dc.creatorIanzer, Danielle Alves-
Data de aceite: dc.date.accessioned2025-08-21T15:56:50Z-
Data de disponibilização: dc.date.available2025-08-21T15:56:50Z-
Data de envio: dc.date.issued2017-11-27-
Data de envio: dc.date.issued2017-11-27-
Data de envio: dc.date.issued2017-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/9187-
Fonte completa do material: dc.identifierhttps://link.springer.com/article/10.1007/s10989-017-9575-7-
Fonte completa do material: dc.identifierhttps://doi.org/10.1007/s10989-017-9575-7-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1028236-
Descrição: dc.descriptionProline-rich oligopeptides from Bothrops jararaca (Bj-PROs) produce potent and long-lasting antihypertensive effect through mechanisms that go beyond ACE inhibition. In this study we evaluated the renal function parameters of spontaneously hypertensive rats (SHR) injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/ kg) found in the CNP-precursor of the snake. At 71 and 710 nmol/kg, Bj-PROs increased urinary flow rate (18.1– 43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated sodium excretion (68.1 and 40.9%, respectively) and Bj- PRO-5a also increased urinary sodium/creatinine ratio (56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal function. All doses of Bj-PROs reduced blood pressure (Δ = −13 to −24mmHg). We conclude that Bj-PROs reduce blood pressure and improve renal functi-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectBlood pressure-
Palavras-chave: dc.subjectHeart rate-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectProlinerich oligopeptides-
Palavras-chave: dc.subjectRenal function-
Título: dc.titleBj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats.-
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