Piperine as therapeutic agent in paracetamol-induced hepatotoxicity in mice.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCoelho, Aline Meireles-
Autor(es): dc.creatorQueiroz, Isabela Ferreira-
Autor(es): dc.creatorPerucci, Luiza Oliveira-
Autor(es): dc.creatorSouza, Melina Oliveira de-
Autor(es): dc.creatorLima, Wanderson Geraldo-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Autor(es): dc.creatorCosta, Daniela Caldeira-
Data de aceite: dc.date.accessioned2025-08-21T15:55:11Z-
Data de disponibilização: dc.date.available2025-08-21T15:55:11Z-
Data de envio: dc.date.issued2023-10-17-
Data de envio: dc.date.issued2023-10-17-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17611-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/pharmaceutics14091800-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1027464-
Descrição: dc.descriptionHigh doses of paracetamol (APAP) can cause irreversible liver damage. Piperine (P) inhibits cytochrome P450, which is involved in the metabolism of various xenobiotics, including paracetamol. We evaluated the hepatoprotective effects of piperine with or without N-acetylcysteine (NAC) in APAP-induced hepatotoxicity. The mice were treated with two doses of piperine (P20 or P40) and/or NAC at 2 h after administration of APAP. The NAC+P20 and NAC+P40 groups showed a reduced area of necrosis, MMP-9 activity, and Casp-1 expression. Furthermore, the NAC+P20 group was the only treatment that reduced alanine aminotransferase (ALT) and increased the levels of sulfhydryl groups (-SH). In the NAC+P40 group, NLRP-3 expression was reduced. Aspartate aminotransferase (AST), thiobarbituric acid-reactive substances (TBARS), and IL-1β expression decreased in the NAC, NAC+P20, and NAC+P40 groups compared to the APAP group. The liver necrosis area, TNF levels, carbonylated protein, and IL-18 expression decreased in the P40, NAC, NAC+P20, and NAC+P40 groups compared to the APAP group. The cytokine IL-6 was reduced in all treatments. Piperine can be used in combination with NAC to treat APAP-induced hepatotoxicity.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.-
Palavras-chave: dc.subjectParacetamol-
Palavras-chave: dc.subjectAcetaminophen-
Palavras-chave: dc.subjectPiperine-
Palavras-chave: dc.subjectRedox status-
Palavras-chave: dc.subjectInflamassome-
Título: dc.titlePiperine as therapeutic agent in paracetamol-induced hepatotoxicity in mice.-
Aparece nas coleções:Repositório Institucional - UFOP

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