Lasting effects of ketamine and isoflurane administration on anxiety- and panic-like behavioral responses in Wistar rats.

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Autor(es): dc.creatorChírico, Máira Tereza Talma-
Autor(es): dc.creatorGuedes, Mariana Reis-
Autor(es): dc.creatorVieira, Lucas Gabriel-
Autor(es): dc.creatorReis, Thayane Oliveira-
Autor(es): dc.creatorSantos, Aline Maria de-
Autor(es): dc.creatorSouza, Ana Beatriz Farias de-
Autor(es): dc.creatorRibeiro, Iara Mariana Léllis-
Autor(es): dc.creatorNoronha, Sylvana Izaura Salyba Rendeiro de-
Autor(es): dc.creatorNogueira, Katiane de Oliveira Pinto Coelho-
Autor(es): dc.creatorOliveira, Laser Antônio Machado de-
Autor(es): dc.creatorGomes, Fabiana Aparecida Rodrigues-
Autor(es): dc.creatorSilva, Fernanda Cacilda dos Santos-
Autor(es): dc.creatorChianca Júnior, Deoclécio Alves-
Autor(es): dc.creatorBezerra, Frank Silva-
Autor(es): dc.creatorMenezes, Rodrigo Cunha Alvim de-
Data de aceite: dc.date.accessioned2025-08-21T15:54:36Z-
Data de disponibilização: dc.date.available2025-08-21T15:54:36Z-
Data de envio: dc.date.issued2021-11-21-
Data de envio: dc.date.issued2021-11-21-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/13979-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/abs/pii/S0024320521004082-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.lfs.2021.119423-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1027207-
Descrição: dc.descriptionIn clinical and laboratory practice, the use of anesthetics is essential in order to perform surgeries. Anesthetics, besides causing sedation and muscle relaxation, promote several physiological outcomes, such as psychotomimetic alterations, increased heart rate, and blood pressure. However, studies depicting the behavioral effect induced by ketamine and isoflurane are conflicting. In the present study, we assessed the behavioral effects precipitated by ketamine and isoflurane administration. We have also evaluated the ketamine effect on cell cytotoxicity and viability in an amygdalar neuronal primary cell culture. Ketamine (80 mg/kg) caused an anxiogenic effect in rats exposed to the elevated T-maze test (ETM) 2 and 7 days after ketamine administration. Ketamine (40 and 80 mg/kg) administration also decreased panic-like behavior in the ETM. In the light/dark test, ketamine had an anxiogenic effect. Isoflurane did not change animal behavior on the ETM. Neither ketamine nor isoflurane changed the spontaneous locomotor activity in the open field test. However, isoflurane-treated animals explored less frequently the OF central area seven days after treatment. Neither anesthetic caused oxidative damage in the liver. Ketamine also reduced cellular metabolism and led to neuronal death in amygdalar primary cell cultures. Thus, our work provides evidence that ketamine and isoflurane induce pronounced long lasting anxiety-related behaviors in male rats.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectAmygdala neurons-
Palavras-chave: dc.subjectCellular viability-
Palavras-chave: dc.subjectAnxiogenic-like response-
Título: dc.titleLasting effects of ketamine and isoflurane administration on anxiety- and panic-like behavioral responses in Wistar rats.-
Aparece nas coleções:Repositório Institucional - UFOP

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