Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLinder, Elizabeth-
Autor(es): dc.creatorDorrance, Anne M.-
Autor(es): dc.creatorMills, Thomas M.-
Autor(es): dc.creatorWebb, Robert Clinton-
Autor(es): dc.creatorLeite, Romulo-
Data de aceite: dc.date.accessioned2025-08-21T15:54:18Z-
Data de disponibilização: dc.date.available2025-08-21T15:54:18Z-
Data de envio: dc.date.issued2017-03-24-
Data de envio: dc.date.issued2017-03-24-
Data de envio: dc.date.issued2009-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7462-
Fonte completa do material: dc.identifierhttp://www.sciencedirect.com/science/article/pii/S1743609515326801-
Fonte completa do material: dc.identifierhttps://doi.org/10.1111/j.1743-6109.2008.01185.x-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1027078-
Descrição: dc.descriptionIntroduction - Hypertension is closely associated with erectile dysfunction (ED) as it has been observed in many experimental models of hypertension. Additionally, epidemiological studies show that approximately a third of the hypertensive patients have ED. Aim—To test the hypothesis that the two-kidney one-clip (2K-1C) rat model of hypertension displays normal erectile function due to increased nitric oxide (NO) production in the penis. Methods—Ganglionic-induced increase in intracavernosal pressure (ICP)/mean arterial pressure (MAP) ratio was used as an index of erectile function in 2K-1C and in normotensive shamoperated (SHAM) anesthetized rats. Cavernosal strips from hypertensive and normotensive rats were used for isometric tension measurement. The contraction induced by alpha-adrenergic agonist phenylephrine, and the relaxation induced by the nitric oxide (NO) donor sodium nitroprusside (SNP) and by the Rho-kinase inhibitor Y-27632 were performed in the absence and in the presence of the nitric oxide synthase (NOS) inhibitor L-NNA. Results—Changes in ICP/MAP induced by ganglionic stimulation were not different between 2K-1C and SHAM rats. The contractile response induced by phenylephrine as well as the relaxation induced by SNP or the Y-27632 were similar in cavernosal strips from both groups. However, in the presence of L-NNA, the relaxation induced by Y-27632 was significantly impaired in 2K-1C compared to SHAM). Conclusions—These data suggest that hypertension and ED could be dissociated from high levels of blood pressure in some animal models of hypertension. Erectile function in 2K-1C hypertensive rats is maintained in spite of the increased Rho-kinase activity by increased NO signaling.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectRho-kinase-
Título: dc.titleErectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production.-
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