A TALE of transposition : Tn3-like transposons play a major role in the spread of pathogenicity determinants of Xanthomonas citri and other Xanthomonads.

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Autor(es): dc.creatorFerreira, Rafael Marini-
Autor(es): dc.creatorOliveira, Amanda Carolina Paulino de-
Autor(es): dc.creatorMoreira, Leandro Marcio-
Autor(es): dc.creatorBelasque Junior, José-
Autor(es): dc.creatorGourbeyre, Edith-
Autor(es): dc.creatorSiguier, Patricia-
Autor(es): dc.creatorFerro, Maria Inês Tiraboschi-
Autor(es): dc.creatorFerro, Jesus Aparecido-
Autor(es): dc.creatorChandler, Michael-
Autor(es): dc.creatorVarani, Alessandro de Mello-
Data de aceite: dc.date.accessioned2025-08-21T15:54:04Z-
Data de disponibilização: dc.date.available2025-08-21T15:54:04Z-
Data de envio: dc.date.issued2017-08-03-
Data de envio: dc.date.issued2017-08-03-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/8417-
Fonte completa do material: dc.identifierhttps://doi.org/10.1128/mBio.02505-14-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1026965-
Descrição: dc.descriptionMembers of the genus Xanthomonas are among the most important phytopathogens. A key feature of Xanthomonas pathogenesis is the translocation of type III secretion system (T3SS) effector proteins (T3SEs) into the plant target cells via a T3SS. Several T3SEs and a murein lytic transglycosylase gene (mlt, required for citrus canker symptoms) are found associated with three transposition-related genes in Xanthomonas citri plasmid pXAC64. These are flanked by short inverted repeats (IRs). The region was identified as a transposon, TnXax1, with typical Tn3 family features, including a transposase and two recombination genes. Two 14-bp palindromic sequences within a 193-bp potential resolution site occur between the recombination genes. Additional derivatives carrying different T3SEs and other passenger genes occur in different Xanthomonas species. The T3SEs include transcription activator-like effectors (TALEs). Certain TALEs are flanked by the same IRs as found in TnXax1 to form mobile insertion cassettes (MICs), suggesting that they may be transmitted horizontally. A significant number of MICs carrying other passenger genes (including a number of TALE genes) were also identified, flanked by the same TnXax1 IRs and delimited by 5-bp target site duplications. We conclude that a large fraction of T3SEs, including individual TALEs and potential pathogenicity determinants, have spread by transposition and that TnXax1, which exhibits all of the essential characteristics of a functional transposon, may be involved in driving MIC transposition. We also propose that TALE genes may diversify by fork slippage during the replicative Tn3 family transposition. These mechanisms may play a crucial role in the emergence of Xanthomonas pathogenicity.-
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Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited. Fonte: O próprio artigo.-
Título: dc.titleA TALE of transposition : Tn3-like transposons play a major role in the spread of pathogenicity determinants of Xanthomonas citri and other Xanthomonads.-
Aparece nas coleções:Repositório Institucional - UFOP

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