Cell immune response in mice skin stimulated with different adjuvants by intradermal route.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMathias, Fernando Augusto Siqueira-
Autor(es): dc.creatorCardoso, Jamille Mirelle de Oliveira-
Autor(es): dc.creatorReis, Levi Eduardo Soares-
Autor(es): dc.creatorSouza, Juliana Vitoriano de-
Autor(es): dc.creatorMoreira, Nádia das Dores-
Autor(es): dc.creatorOstolin, Thais Lopes Valentim Di Paschoale-
Autor(es): dc.creatorBrito, Rory Cristiane Fortes de-
Autor(es): dc.creatorSoares, Rodrigo Dian de Oliveira Aguiar-
Autor(es): dc.creatorVieira, Paula Melo de Abreu-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorRoatt, Bruno Mendes-
Autor(es): dc.creatorReis, Alexandre Barbosa-
Data de aceite: dc.date.accessioned2025-08-21T15:52:30Z-
Data de disponibilização: dc.date.available2025-08-21T15:52:30Z-
Data de envio: dc.date.issued2023-01-25-
Data de envio: dc.date.issued2023-01-25-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/16058-
Fonte completa do material: dc.identifierhttps://www.gavinpublishers.com/article/view/cell-immune-response-in-mice-skin-stimulated-with-different-adjuvants-by-intradermal-route-
Fonte completa do material: dc.identifierhttps://doi.org/10.29011/2575-789X.000170-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1026244-
Descrição: dc.descriptionAdjuvants act in the innate immunity and, when combined to vaccine antigens, can produce a more intense response, improving the antigen presentation, directing the immune system, excellent for new vaccine formulations. This study evaluated the use of the intradermal route and the immune response triggered by a single dose of the adjuvants Aluminum Hydroxide (Al(OH)3 ), Montanide Pet Gel A (MPGA), Glucopyranosyl Lipid A Stable Emulsion (GLA-SE), and Resiquimod (R-848) in the mice skin. As control mice received sterile saline. MPGA and GLA-SE led to cell recruitment when compared with control group, with intense presence of neutrophils in first 12 hours, replaced by macrophages after 168 hours. R-848 and Al(OH)3 showed similar cell recruitment profiles. Regarding cytokine production, groups that received MPGA and GLA-SE produced high levels of IL-6, TNF-α, and IFN-γ. R-848 and Al(OH)3 groups displayed similar profile of cytokine production only at the first hour. Our results suggest that the intradermal route is efficient inducing immune system activation and GLA-SE was promising adjuvants for a type 1 immune response vaccine.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectAluminum hydroxide-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectGlucopyranosyl Lipid A Stable Emulsion-
Palavras-chave: dc.subjectImmune response-
Palavras-chave: dc.subjectInflammatory cell infiltrates-
Título: dc.titleCell immune response in mice skin stimulated with different adjuvants by intradermal route.-
Aparece nas coleções:Repositório Institucional - UFOP

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