Antihypertensive effect of a nanoemulsion of Baccharis dracunculifolia leaves extract in sodium-dependent hypertensive rats.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBatista, Marcos Adriano Carlos-
Autor(es): dc.creatorFreitas, Flávio Eduardo Dias Araújo-
Autor(es): dc.creatorBraga, Daiane Cristina de Assis-
Autor(es): dc.creatorSouza, Jaqueline Aparecida de-
Autor(es): dc.creatorAntunes, Vagner Roberto-
Autor(es): dc.creatorSouza, Gustavo Henrique Bianco de-
Autor(es): dc.creatorSantos, Orlando David Henrique dos-
Autor(es): dc.creatorBrandão, Geraldo Célio-
Autor(es): dc.creatorKohlhof, Markus-
Autor(es): dc.creatorCeron, Carla Speroni-
Autor(es): dc.creatorMoura, Sandra Aparecida Lima de-
Autor(es): dc.creatorCardoso, Leonardo Máximo-
Data de aceite: dc.date.accessioned2025-08-21T15:51:48Z-
Data de disponibilização: dc.date.available2025-08-21T15:51:48Z-
Data de envio: dc.date.issued2025-01-29-
Data de envio: dc.date.issued2025-01-29-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19659-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/pdf/10.1080/14786419.2024.2397724-
Fonte completa do material: dc.identifierhttps://doi.org/10.1080/14786419.2024.2397724-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1026059-
Descrição: dc.descriptionBaccharis dracunculifolia (DC) is an important botanical source of Brazilian green propolis and have many compounds with potential antihypertensive activity. However, little is known about the specific antihypertensive properties of DC, or the mechanisms involved. Here we aimed to chemically characterise an ethanolic DC extract (eDC), test its antihypertensive properties and the involvement of neurogenic mechanisms using an animal model of salt-dependent hypertension. The chemical analysis of the eDC revealed the presence of many antihypertensive compounds. Administering the eDC in a nanoemulsion formulation (25 to 50 mg/kg) effectively normalised blood pressure in hypertensive rats. The result also suggested that neurogenic mechanisms are involved in the antihypertensive action of eDC. The treatment with p-coumaric acid (0.32 to 3 mg/kg), a polyphenol abundant in the eDC, produced no significant antihypertensive effect. The findings indicate that the eDC has antihypertensive properties, and that these effects may be mediated through neurogenic pressor mechanisms.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectBaccharis dracunculifolia-
Palavras-chave: dc.subjectBrazilian green propolis-
Palavras-chave: dc.subjectP-coumaric acid-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectSalt-
Título: dc.titleAntihypertensive effect of a nanoemulsion of Baccharis dracunculifolia leaves extract in sodium-dependent hypertensive rats.-
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