Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E downregulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBarbosa, Helloana Azevedo-
Autor(es): dc.creatorSilva, Guilherme Álvaro Ferreira da-
Autor(es): dc.creatorSilva, Carolina Faria-
Autor(es): dc.creatorSouza, Thiago Belarmino de-
Autor(es): dc.creatorDias, Danielle Ferreira-
Autor(es): dc.creatorPaula, Ana Cláudia Chagas de-
Autor(es): dc.creatorIonta, Marisa-
Autor(es): dc.creatorCarvalho, Diogo Teixeira-
Data de aceite: dc.date.accessioned2025-08-21T15:51:12Z-
Data de disponibilização: dc.date.available2025-08-21T15:51:12Z-
Data de envio: dc.date.issued2020-05-22-
Data de envio: dc.date.issued2020-05-22-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/12249-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0887233318305290-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.tiv.2019.04.023-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1025804-
Descrição: dc.descriptionCancer is one of the most critical problems of public health in the world and one of the main challenges for medicine. Different biological effects have been reported for sulfonamide-based compounds including antibacterial, antifungal, and antitumor activities. Herein, a series of phenylpropanoid-based sulfonamides (4a, 4a′, 4b, 4b′, 5a, 5a′, 5b and 5b′) were synthesized and their cytotoxic activity was evaluated against four cell lines derived from human tumours (A549 – lung, MCF-7 – breast, Hep G2 - hepatocellular carcinoma, and HT-144-melanoma). Cell viability was significantly reduced in the MCF-7 cell line when compounds 4b, 4b′ and 5a were used; IC50 values were lower than those found for their precursors (eugenol and dihydroeugenol) and sulfanilamide. We observed that 4b induced cell cycle arrest at G1/S transition. This is probably due to its ability to reduce cyclin D1 and cyclin E expression. Moreover, 4b also induced apoptosis in MCF-7 cells as demonstrated by an increase in the cell population positive for annexin V in treated cultures in comparison to the control group. Taken together, the data showed that 4b is a promising antitumor agent and it should be considered for further in vivo studies.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectSulfonamides-
Palavras-chave: dc.subjectMolecular hybridization-
Palavras-chave: dc.subjectAntiproliferative activity-
Palavras-chave: dc.subjectBreast cancer-
Título: dc.titlePhenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E downregulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line.-
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