Phytochemical study of Magonia pubescens A. St.-Hil. and cytotoxicity of branches aqueous extract on breast cancer and leukemia cells.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMoraes, Acácio Raphael Aguiar-
Autor(es): dc.creatorSiqueira Filho, Ezequias Pessoa de-
Autor(es): dc.creatorKohlhoff, Markus-
Autor(es): dc.creatorEvangelista, Fernanda Cristina Gontijo-
Autor(es): dc.creatorSabino, Adriano de Paula-
Autor(es): dc.creatorVieira Filho, Sidney Augusto-
Autor(es): dc.creatorAlcântara, Antônio Flávio de Carvalho-
Autor(es): dc.creatorDuarte, Lucienir Pains-
Autor(es): dc.creatorSousa, Grasiely Faria de-
Data de aceite: dc.date.accessioned2025-08-21T15:50:54Z-
Data de disponibilização: dc.date.available2025-08-21T15:50:54Z-
Data de envio: dc.date.issued2025-02-06-
Data de envio: dc.date.issued2025-02-06-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19735-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/full/10.1080/14786419.2023.2227988-
Fonte completa do material: dc.identifierhttps://doi.org/10.1080/14786419.2023.2227988-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1025673-
Descrição: dc.descriptionMagonia pubescens is a natural species from the Brazilian cerrado biome. Its fruits and seeds are used in the treatment of seborrheic dermatitis, a common inflammatory skin disease. In this work, the known compounds lapachol, stigmasterol, maniladiol and scopoletin were isolated from hexane and dichloromethane extracts of M. pubescens branches. The aqueous extract of this material was fractioned through a liquid-liquid partition and the obtained fractions were analyzed by UHPLC-MS/MS. The results obtained were compared with data from three databases, leading to the putative identification of 51 compounds from different classes, including flavonoids, saponins and triterpenes. The cytotoxicity of aqueous fractions was assayed against breast cancer (MDA -MB-231) and leukemia (THP-1 and K562) cells. The best activity was observed for fraction AE3 against MDA -MB-231 cells (IC50 30.72 μg.mL−1).-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectMagonia pubescens A. St.-Hil-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectBreast cancer cells-
Palavras-chave: dc.subjectLeukemia cells-
Título: dc.titlePhytochemical study of Magonia pubescens A. St.-Hil. and cytotoxicity of branches aqueous extract on breast cancer and leukemia cells.-
Aparece nas coleções:Repositório Institucional - UFOP

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