Pyrazinoic acid-poly(malic acid) biodegradable nanoconjugate for efficient intracellular delivery.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCarneiro, Simone Pinto-
Autor(es): dc.creatorMoine, Laurence-
Autor(es): dc.creatorTessier, Barbara-
Autor(es): dc.creatorValérie, Nicolas-
Autor(es): dc.creatorSantos, Orlando David Henrique dos-
Autor(es): dc.creatorFattal, Elias-
Data de aceite: dc.date.accessioned2025-08-21T15:50:02Z-
Data de disponibilização: dc.date.available2025-08-21T15:50:02Z-
Data de envio: dc.date.issued2020-05-22-
Data de envio: dc.date.issued2020-05-22-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/12246-
Fonte completa do material: dc.identifierhttps://doi.org/10.33218/prnano2(3).190523.1-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1025288-
Descrição: dc.descriptionTuberculosis is an infectious disease affecting mostly lungs, that is still considered a health global problem as it causes millions of deaths worldwide. Current treatment is effective but associated with severe adverse effects due to the high doses of each anti-tuberculosis drug daily administrated by oral therapy. For the first time, a pyrazinoic acid (PA) biodegradable nanoconjugate was synthesized and developed for pulmonary administration in an attempt to reduce the administered doses by achieving a high drug payload and controlled release at the target site. The conjugate was synthesized by coupling pyrazinoic acid on carboxylic groups of poly(malic acid), which is a biodegradable and biocompatible polymer, and posteriorly self-assembled into nanoconjugates. Characterization confirmed the formation of nanometric, spherical and negatively charged pyrazinoic acid nanoconjugate (NC-PA). NC-PA was stable for 60 days at 4 and 37°C and able to deliver PA in a sustained release manner over time. On macrophages, they exhibited no cell toxicity for a wide range of concentrations (from 1 to 100 µg/mL), demonstrating the safety of NC-PA. In addition, the nanoconjugate was efficiently taken up by RAW 264.7 cells over 6 hours reaching a maximum value after 3 hours of incubation. In conclusion, innovative nanoconjugates are a promising alternative to deliver drugs directly to the lungs and contributing to improving tuberculosis therapy.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsLicense: CC BY-NC-SA 4.0. Fonte: o próprio artigo.-
Palavras-chave: dc.subjectTuberculosis-
Título: dc.titlePyrazinoic acid-poly(malic acid) biodegradable nanoconjugate for efficient intracellular delivery.-
Aparece nas coleções:Repositório Institucional - UFOP

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