Acute outcomes of cigarette smoke and electronic cigarette aerosol inhalation in a murine model.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Pamela Félix da-
Autor(es): dc.creatorMatos, Natália Alves de-
Autor(es): dc.creatorRamos, Camila de Oliveira-
Autor(es): dc.creatorCastro, Thalles de Freitas-
Autor(es): dc.creatorAraújo, Natália Pereira da Silva-
Autor(es): dc.creatorSouza, Ana Beatriz Farias de-
Autor(es): dc.creatorCosta, Guilherme de Paula-
Autor(es): dc.creatorCangussú, Silvia Dantas-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Autor(es): dc.creatorNagato, Akinori Cardozo-
Autor(es): dc.creatorBezerra, Frank Silva-
Data de aceite: dc.date.accessioned2025-08-21T15:49:22Z-
Data de disponibilização: dc.date.available2025-08-21T15:49:22Z-
Data de envio: dc.date.issued2023-10-26-
Data de envio: dc.date.issued2023-10-26-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17680-
Fonte completa do material: dc.identifierhttps://doi.org/10.1155/2022/9938179-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1024977-
Descrição: dc.descriptionCigarette smoking throughout life causes serious health issues in the lungs. The electronic cigarette (E-Cig) use increased, since it was first introduced in the world. This research work compared the short-term exposure consequences to e-cigarette vapor and cigarette smoke in male mice. Forty-five C57BL/6 mice were randomized into control (C) in an ambient air exposition cigarette smoke (CS) and aerosol electronic cigarette (EC), both were exposed to 120 puffs, 3 times/day during five days. Then, in the experimental protocol, the euthanized mice had their tissues removed for analysis. Our study showed that CS and EC resulted in higher cell influx into the airways, and an increase in macrophage counts in CS (209.25 ± 7.41) and EC (220.32 ± 8.15) when compared to C (108.40 ± 4.49) (p < 0:0001). The CS (1.92 ± 0.23) displayed a higher pulmonary lipid peroxidation as opposed to C (0.93 ± 0.06) and EC (1.23 ± 0.17) (p < 0:05). The EC (282.30 ± 25.68) and CS (368.50 ± 38.05) promoted increased levels of interleukin 17 when compared to C (177.20 ± 10.49) (p < 0:05). The EC developed shifts in lung histoarchitecture, characterized by a higher volume density in the alveolar air space (60.21; 55.00-65.83) related to C (51.25; 18.75-68.75) and CS (50.26; 43.75-62.08) (p =0.002). The EC (185.6 ± 9.01) presented a higher respiratory rate related to CS (133.6 ± 10.2) (p < 0:002). Therefore, our findings demonstrated that the short-term exposure to e-cig promoted more acute inflammation comparing to cigarette smoke in the ventilatory parameters of the animals.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: PDF do artigo.-
Título: dc.titleAcute outcomes of cigarette smoke and electronic cigarette aerosol inhalation in a murine model.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.