Immune response induced by New World Leishmania species in C57BL/6 mice.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorMaioli, Tatiani Uceli-
Autor(es): dc.creatorTakane, Erica-
Autor(es): dc.creatorArantes, Rosa Maria Esteves-
Autor(es): dc.creatorFietto, Juliana Lopes Rangel-
Autor(es): dc.creatorAfonso, Luís Carlos Crocco-
Data de aceite: dc.date.accessioned2025-08-21T15:48:33Z-
Data de disponibilização: dc.date.available2025-08-21T15:48:33Z-
Data de envio: dc.date.issued2017-06-13-
Data de envio: dc.date.issued2017-06-13-
Data de envio: dc.date.issued2004-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7965-
Fonte completa do material: dc.identifierhttp://link.springer.com/article/10.1007%2Fs00436-004-1193-6-
Fonte completa do material: dc.identifierhttps://doi.org/10.1007/s00436-004-1193-6-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1024614-
Descrição: dc.descriptionIn the present study, C57BL/6 mice were inoculated with metacyclic Leishmania amazonensis or L. braziliensis promastigotes. While these animals were capable of controlling the infection by L. braziliensis, they developed chronic lesions with elevated numbers of parasites when infected by L. amazonensis. The differences in parasite control were associated with a decreased production of IFN-c and TNF by lymph node cells from L. amazonensis-infected mice. Furthermore, these animals presented decreased spleen cell proliferation and activation of germinal centers. In addition, we compared the ability of these parasites to hydrolyze extracellular ATP and AMP. While the ATPase activity of both parasite species was similar, L. amazonensis promastigotes presented higher AMP hydrolytic activity. This increased activity may lead to an increased production of adenosine, which has been shown to present anti-inflammatory activity and may thus be involved in the establishment of the immunosuppression observed in mice infected by L. amazonensis.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleImmune response induced by New World Leishmania species in C57BL/6 mice.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.