Metabolic consequences of interesterified palm oil and PCB-126 co-exposure in C57BL/6 mice.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorTeixeira, Ananda Vitoria Silva-
Autor(es): dc.creatorQuitete, Fernanda Torres-
Autor(es): dc.creatorMartins, Bruna Cadete-
Autor(es): dc.creatorPeixoto, Thamara Cherem-
Autor(es): dc.creatorRibeiro, Mayara da Silva-
Autor(es): dc.creatorVelasco, Patricia Coelho de-
Autor(es): dc.creatorMiranda, Carolline Santos-
Autor(es): dc.creatorResende, Angela de Castro-
Autor(es): dc.creatorCosta, Daniela Caldeira-
Autor(es): dc.creatorAtella, Geórgia Correa-
Autor(es): dc.creatorMucci, Daniela de Barros-
Autor(es): dc.creatorMello, Vanessa Souza-
Autor(es): dc.creatorMartins, Fabiane Ferreira-
Autor(es): dc.creatorDaleprane, Julio Beltrame-
Data de aceite: dc.date.accessioned2025-08-21T15:48:02Z-
Data de disponibilização: dc.date.available2025-08-21T15:48:02Z-
Data de envio: dc.date.issued2025-02-27-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19804-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0278691524005313?via%3Dihub-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.fct.2024.114965-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1024384-
Descrição: dc.descriptionMetabolic dysfunction-associated steatotic liver disease (MASLD) is defined as morphofunctional changes in the liver. Studies have shown that Westernized eating patterns and environmental pollutants can directly induce the development of MASLD. This study evaluates the effect of co-exposure to interesterified palm oil (IPO) and 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126) on the progression of MASLD in an animal model. C57BL/6 mice were fed IPO and co-exposed to PCB-126 for ten weeks. The co-exposure led to an imbalance in carbohydrate metabolism, increased systemic inflammation markers, and morphofunctional changes in the liver. These liver changes included the presence of inflammatory cells, fibrosis, alterations in aspartate transaminase (AST) and alanine transaminase (ALT) enzymes, and imbalance in gene expression related to fatty acid β-oxidation, de novo lipogenesis, mitochondrial dynamics, and endoplasmic reticulum stress. Separate exposures to IPO and PCB-126 affected metabolism and MASLD progression. Nutritional and lifestyle factors may potentiate the onset and severity of MASLD.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectMetabolic dysfunction-
Palavras-chave: dc.subjectHepatic steatosis-
Palavras-chave: dc.subjectInflammatory markers-
Palavras-chave: dc.subjectMitochondrial dysfunction-
Palavras-chave: dc.subjectEndoplasmic reticulum stress-
Título: dc.titleMetabolic consequences of interesterified palm oil and PCB-126 co-exposure in C57BL/6 mice.-
Aparece nas coleções:Repositório Institucional - UFOP

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