Polymorphic characterization and implications on biopharmaceutics properties of potential anti-inflammatory drug candidate eremantholide C from Lychnophora trichocarpha (Brazilian Arnica).

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCaldeira, Tamires Guedes-
Autor(es): dc.creatorGuimarães, Dênia Antunes Saúde-
Autor(es): dc.creatorLacerda, Dâmaris Laignier Rodrigues de-
Autor(es): dc.creatorMussel, Wagner da Nova-
Autor(es): dc.creatorYoshida, Maria Irene-
Autor(es): dc.creatorSouza, Jacqueline de-
Data de aceite: dc.date.accessioned2025-08-21T15:47:50Z-
Data de disponibilização: dc.date.available2025-08-21T15:47:50Z-
Data de envio: dc.date.issued2020-05-15-
Data de envio: dc.date.issued2020-05-15-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/12197-
Fonte completa do material: dc.identifierhttps://onlinelibrary.wiley.com/doi/full/10.1111/jphp.13080-
Fonte completa do material: dc.identifierhttps://doi.org/10.1111/jphp.13080-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1024302-
Descrição: dc.descriptionObjectives: To perform the polymorphic and physicochemical characterization of the potential anti-inflammatory drug, eremantholide C (EREC), as well as to evaluate the influence of these characteristics on its biopharmaceutics classification. Methods Eremantholide C was obtained from chloroformic extract of Lychnophora trichocarpha and crystallized in two distinct solvents: chloroform (EREC 1) and ethyl acetate (EREC 2). To evaluate the polymorphism, EREC samples were submitted to melting point, purity, infrared spectroscopy, differential scanning calorimetry (DSC), X-ray powder diffraction, optical microscopy and scanning electron microscopy analysis. In addition, EREC samples crystallized after intrinsic dissolution study were submitted to DSC and X-ray powder diffraction analysis. Key findings EREC 1 showed fusion at 234.7–241.6 °C, while EREC 2 showed fusion at 238.6–243.7 °C. No polymorphic transitions were observed during the intrinsic dissolution experiment. A single sharp endothermic peak was obtained for the EREC samples. X-ray diffraction showed no crystallographic differences between the EREC samples. EREC 1 and EREC 2 showed birefringence under polarized light and indefinite morphology; however, the shape of the crystals was common to the two samples. Conclusions: Eremantholide C does not present classical or morphological polymorphism; therefore, there is no influence of crystalline transitions in the solubility and consequently in its biopharmaceutics classification and oral absorption process.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectDifferential scanning calorimetry-
Palavras-chave: dc.subjectIntrinsic dissolution-
Palavras-chave: dc.subjectSolubility-
Palavras-chave: dc.subjectX-ray powder diffraction-
Título: dc.titlePolymorphic characterization and implications on biopharmaceutics properties of potential anti-inflammatory drug candidate eremantholide C from Lychnophora trichocarpha (Brazilian Arnica).-
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