Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Riva de Paula-
Autor(es): dc.creatorAbate, Jess Porter-
Autor(es): dc.creatorDilks, Kieran-
Autor(es): dc.creatorLandis, Jessica-
Autor(es): dc.creatorAshraf, Jasmine-
Autor(es): dc.creatorMurphy, Coleen T.-
Autor(es): dc.creatorBlackwell, T. Keith-
Data de aceite: dc.date.accessioned2025-08-21T15:47:00Z-
Data de disponibilização: dc.date.available2025-08-21T15:47:00Z-
Data de envio: dc.date.issued2017-08-11-
Data de envio: dc.date.issued2017-08-11-
Data de envio: dc.date.issued2009-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/8525-
Fonte completa do material: dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2009.00501.x/abstract-
Fonte completa do material: dc.identifierhttps://doi.org/10.1111/j.1474-9726.2009.00501.x-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023982-
Descrição: dc.descriptionStudies in model organisms have identified regulatory processes that profoundly influence aging, many of which modulate resistance against environmental or metabolic stresses. In Caenorhabditis elegans, the transcription regulator SKN-1 is important for oxidative stress resistance and acts in multiple longevity pathways. SKN-1 is the ortholog of mammalian Nrf proteins, which induce Phase 2 detoxification genes in response to stress. Phase 2 enzymes defend against oxygen radicals and conjugate electrophiles that are produced by Phase 1 detoxification enzymes, which metabolize lipophilic compounds. Here, we have used expression profiling to identify genes and processes that are regulated by SKN-1 under normal and stress–response conditions. Under nonstressed conditions SKN-1 upregulates numerous genes involved in detoxification, cellular repair, and other functions, and downregulates a set of genes that reduce stress resistance and lifespan. Many of these genes appear to be direct SKN-1 targets, based upon presence of predicted SKN-binding sites in their promoters. The metalloid sodium arsenite induces skn-1-dependent activation of certain detoxification gene groups, including some that were not SKN-1- upregulated under normal conditions. An organic peroxide also triggers induction of a discrete Phase 2 gene set, but additionally stimulates a broad SKN-1-independent response. We conclude that under normal conditions SKN-1 has a wide range of functions in detoxification and other processes, including modulating mechanisms that reduce lifespan. In response to stress, SKN-1 and other regulators tailor transcription programs to meet the challenge at hand. Our findings reveal striking complexity in SKN-1 functions and the regulation of systemic detoxification defenses.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectAging-
Palavras-chave: dc.subjectCaenorhabditis elegans-
Palavras-chave: dc.subjectInsulin signaling-
Palavras-chave: dc.subjectDetoxification-
Título: dc.titleCondition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.