Predicted vitamin D levels and risk of depression in the SUN Project : a prospective cohort study.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSabião, Thaís da Silva-
Autor(es): dc.creatorValer Martínez, Ana-
Autor(es): dc.creatorSayon Orea, Carmen-
Autor(es): dc.creatorSánchez Villegas, Almudena-
Autor(es): dc.creatorPons Izquierdo, Juan José-
Autor(es): dc.creatorCarraro, Júlia Cristina Cardoso-
Autor(es): dc.creatorMartínez González, Miguel Ángel-
Autor(es): dc.creatorBes Rastrollo, Maira-
Data de aceite: dc.date.accessioned2025-08-21T15:46:41Z-
Data de disponibilização: dc.date.available2025-08-21T15:46:41Z-
Data de envio: dc.date.issued2025-03-06-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19830-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.jpsychires.2024.09.034-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023849-
Descrição: dc.descriptionThe current study aimed to investigate the association between predicted vitamin D status and depression in a prospective Spanish cohort of university graduates. The SUN Project is a dynamic cohort study designed to investigate multiple aspects of health and lifestyle. Participants were asked to complete a comprehensive questionnaire consisting of 556 items, that included a validated food-frequency questionnaire. Participants initially free of depression were classified as incident cases if they reported a medical diagnosis of depression during follow-up. Serum vitamin D levels were predicted by a previously validated equation. Vitamin D deficiency was defined as vitamin D levels below 20 ng/mL. Cox models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI). We included 15,175 Spanish university graduates [mean (SD) age: 36.9 year (11.5)] followed-up for a median of 12.7 years. Among 192,976 person-years of follow-up, we identified 753 incident cases of depression. Participants with vitamin D deficiency had a 27% higher risk of depression as compared to those with vitamin D sufficiency (HR: 1.27, 95% CI: 1.09–1.48; p = 0.002) after adjusting for potential confounders. Furthermore, a significant effect modification by female sex was observed with higher depression risks associated with vitamin D deficiency in women than in men (p for interaction = 0.034). In educated middle-aged Spanish adults, we observed a direct association between vitamin D deficiency and the risk of depression, that was stronger among women.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). Fonte: PDF do artigo.-
Palavras-chave: dc.subjectDepression-
Palavras-chave: dc.subjectVitamin D-
Palavras-chave: dc.subjectSun exposure-
Palavras-chave: dc.subjectSUN cohort-
Palavras-chave: dc.subjectProspective studies-
Título: dc.titlePredicted vitamin D levels and risk of depression in the SUN Project : a prospective cohort study.-
Aparece nas coleções:Repositório Institucional - UFOP

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