Synthesis, trypanocidal and cytotoxic activities of α,β-unsaturated ketones derived from eugenol and analogues.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorReis, Rúbia Castro Fernandes Melo-
Autor(es): dc.creatorReis, Adriana Cotta Cardoso-
Autor(es): dc.creatorTorchelsen, Fernanda Karoline Vieira da Silva-
Autor(es): dc.creatorLana, Marta de-
Autor(es): dc.creatorSales Júnior, Policarpo Ademar-
Autor(es): dc.creatorBrandão, Geraldo Célio-
Autor(es): dc.creatorBraga, Saulo Fehelberg Pinto-
Autor(es): dc.creatorSouza, Thiago Belarmino de-
Data de aceite: dc.date.accessioned2025-08-21T15:46:27Z-
Data de disponibilização: dc.date.available2025-08-21T15:46:27Z-
Data de envio: dc.date.issued2023-10-10-
Data de envio: dc.date.issued2023-10-10-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17552-
Fonte completa do material: dc.identifierhttps://link.springer.com/article/10.1007/s00044-022-02976-x-
Fonte completa do material: dc.identifierhttps://doi.org/10.1007/s00044-022-02976-x-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023762-
Descrição: dc.descriptionThis work describes the synthesis, structural characterization, trypanocide and cytotoxic evaluation of α,β-unsaturated ketones derived from eugenol and analogues. Among the synthesized compounds, the cyclopentanonic/dihydroeugenol derivative 12 was active against amastigote forms of Trypanosoma cruzi at 5.2 nM (700 times more potent than benznidazole) and represents a potential hit for future structural optimizations to reduce its toxicity. All the compounds were also evaluated against a healthy human and four cancer cell lines and the derivative 10 was more active than doxorubicin against three cancer cells (IC50 values between 2.03–23.51 μM) and showed the higher selectivity index considering the human cells. Derivative 14 was also more potent and selective than doxorubicin against two cancer cells (IC50 values between 4.71–8.86 μM).-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectEugenol-
Palavras-chave: dc.subjectTrypanocide activity-
Título: dc.titleSynthesis, trypanocidal and cytotoxic activities of α,β-unsaturated ketones derived from eugenol and analogues.-
Aparece nas coleções:Repositório Institucional - UFOP

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