Hypotensive effect induced by microinjection of Alamandine, a derivative of angiotensin-(1–7), into caudal ventrolateral medulla of 2K1C hypertensive rats.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSoares, Everton Rocha-
Autor(es): dc.creatorBarbosa, Claudiane Maria-
Autor(es): dc.creatorSantos, Maria José Campagnole dos-
Autor(es): dc.creatorSantos, Robson Augusto Souza dos-
Autor(es): dc.creatorAlzamora, Andréia Carvalho-
Data de aceite: dc.date.accessioned2025-08-21T15:46:13Z-
Data de disponibilização: dc.date.available2025-08-21T15:46:13Z-
Data de envio: dc.date.issued2018-04-11-
Data de envio: dc.date.issued2018-04-11-
Data de envio: dc.date.issued2017-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/9841-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0196978117302772?via%3Dihub-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023678-
Descrição: dc.descriptionIn the present study we evaluated the cardiovascular effects produced by microinjection of the new component of the renin-angiotensin system, alamandine, into caudal ventrolateral medulla of urethane-anesthetized normotensive and hypertensive 2K1C rats. The participation of different angiotensin receptors in the effects of alamandine was also evaluated. Microinjection of angiotensin-(1–7) was used for comparison. The microinjection of 4, 40 and 140 pmol of alamandine or angiotensin-(1–7) into caudal ventrolateral medulla induced similar hypotensive effects in Sham-operated rats. However, contrasting with angiotensin-(1–7), in 2K1C rats the MAP response to the highest dose of alamandine was similar to that observed with saline. The microinjection of A- 779, a selective Mas receptor antagonist, blunted the angiotensin-(1–7) effects but did not block the hypotensive effect of alamandine in Sham or in 2K1C rats. However, microinjection of D-Pro7-angiotensin-(1–7), a Mas/MrgD receptor antagonist, blocked the hypotensive effect induced by both peptides. Furthermore, microinjection of PD123319, a putative AT2 receptor antagonist blocked the hypotensive effect of alamandine, but not of angiotensin-( 1–7), in Sham and 2K1C rats. Microinjection of the AT1 receptor antagonist, losartan, did not alter the hypotensive effect of angiotensin-(1–7) or alamandine in both groups. These results provide new insights about the differential mechanisms participating in the central cardiovascular effects of alamandine and angiotensin- (1–7) in normotensive and 2K1C hypertensive rats.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectAlamandine-
Palavras-chave: dc.subjectAngiotensinergic antagonists-
Palavras-chave: dc.subjectCaudal ventrolateral medulla-
Palavras-chave: dc.subjectAng-(1–7)-
Título: dc.titleHypotensive effect induced by microinjection of Alamandine, a derivative of angiotensin-(1–7), into caudal ventrolateral medulla of 2K1C hypertensive rats.-
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