Amphotericin B-Loaded poly(lactic-co-glycolic acid) nanofibers : an alternative therapy scheme for Local treatment of vulvovaginal candidiasis.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSouza, Ramon Oliveira-
Autor(es): dc.creatorLima, Tadeu Henrique de-
Autor(es): dc.creatorOréfice, Rodrigo Lambert-
Autor(es): dc.creatorAraújo, Marcelo Gonzaga de Freitas-
Autor(es): dc.creatorMoura, Sandra Aparecida Lima de-
Autor(es): dc.creatorMagalhães, Juliana Teixeira de-
Autor(es): dc.creatorSilva, Gisele Rodrigues da-
Data de aceite: dc.date.accessioned2025-08-21T15:46:02Z-
Data de disponibilização: dc.date.available2025-08-21T15:46:02Z-
Data de envio: dc.date.issued2019-04-09-
Data de envio: dc.date.issued2019-04-09-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/10989-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0022354918303514-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023600-
Descrição: dc.descriptionVulvovaginal candidiasis is an inflammation localized in the vulvovaginal area. It is mostly caused by Candida albicans. Its treatment is based on the systemic and local administration of antifungal drugs. However, this conventional therapy can fail owing to the resistance of the Candida species and noncompliance of patients. Amphotericin B-loaded poly(lactic-co-glycolic acid) nanofibers are singleuse, antifungal, controlled drug delivery systems, and represent an alternative therapeutic scheme for the local treatment of vulvovaginal candidiasis. Nanofibers were characterized by analytical techniques and with an in vitro drug delivery study. In vitro and in vivo fungicidal activity of amphotericin B released from nanofibers was evaluated using the agar diffusion method and an experimental murine model of vulvovaginal candidiasis, respectively. Analytical techniques showed that amphotericin B was physically mixed in the polymeric nanofibers. Nanofibers controlled the delivery of therapeutic doses of amphotericin B for eight consecutive days, providing effective in vitro antifungal activity and eliminated the in vivo vaginal fungal burden after 3 days of treatment and with only one local application. Amphotericin B-loaded poly(lactic-co-glycolic acid) nanofibers could be potentially applied as an alternative strategy for the local treatment of vulvovaginal candidiasis without inducing fungal resistance, yet ensuring patient compliance-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectPolymeric nanofibers-
Palavras-chave: dc.subjectElectrospinning technique-
Palavras-chave: dc.subjectLocal drug delivery system-
Palavras-chave: dc.subjectCandida albicans-
Título: dc.titleAmphotericin B-Loaded poly(lactic-co-glycolic acid) nanofibers : an alternative therapy scheme for Local treatment of vulvovaginal candidiasis.-
Aparece nas coleções:Repositório Institucional - UFOP

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