High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil.

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Autor(es): dc.creatorPereira, Anna Carolina Toledo da Cunha-
Autor(es): dc.creatorSiqueira, Tatiane Ribeiro de-
Autor(es): dc.creatorPrado, Andressa Anunciação de Oliveira-
Autor(es): dc.creatorSilva, Camila Almeida Veiga da-
Autor(es): dc.creatorMoraes, Thaís de Fátima Silva-
Autor(es): dc.creatorAleixo, Alan Alex-
Autor(es): dc.creatorMagalhães, José Carlos de-
Autor(es): dc.creatorSouza, Gabriel Augusto Pires de-
Autor(es): dc.creatorDrumond, Betânia Paiva-
Autor(es): dc.creatorFerreira, Gustavo Portela-
Autor(es): dc.creatorSilva, Breno de Mello-
Autor(es): dc.creatorMagalhães, Cíntia Lopes de Brito-
Autor(es): dc.creatorSantos, Luciana Lara-
Autor(es): dc.creatorFerreira, Jaqueline Maria Siqueira-
Autor(es): dc.creatorMalaquias, Luiz Cosme Cotta-
Autor(es): dc.creatorCoelho, Luiz Felipe Leomil-
Data de aceite: dc.date.accessioned2025-08-21T15:45:49Z-
Data de disponibilização: dc.date.available2025-08-21T15:45:49Z-
Data de envio: dc.date.issued2018-05-03-
Data de envio: dc.date.issued2018-05-03-
Data de envio: dc.date.issued2017-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/9892-
Fonte completa do material: dc.identifierhttps://link.springer.com/article/10.1007%2Fs00251-017-1046-y-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023532-
Descrição: dc.descriptionDengue is the most prevalent arthropod-borne viral illness in humans worldwide. Single-nucleotide polymorphisms (SNPs) in genes involved in the immune response, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), IgG Fc receptor II-A (FcγRIIa), vitamin D receptor (VDR), and tumor necrosis factor alpha (TNF-α), were previously reported to be associated with susceptibility to dengue disease in different human populations. Therefore, due to the relevant association of host immune and genetic status with disease susceptibility/severity of dengue, this work aims to verify the frequency of anti-dengue virus antibodies and some dengue-associated risk SNPs in a population in Minas Gerais State, Southeast Brazil. A total of 1560 individuals were genotyped for polymorphisms in DC-SIGN (rs4804803), FcγRIIa (rs1801274), VDR (rs7975232), and TNF-α (rs1800629). The presence of anti-dengue antibodies (IgM and/or IgG) in these samples was also assayed. Anti-dengue antibodies were detected at an overall frequency of 16.86%, indicating a virus infection in asymptomatic individuals. The genotypic frequencies of all SNPs studied did not differ between the asymptomatic and control groups. Regarding the allelic frequencies of the four SNPs analyzed, a higher frequency was detected of the G allele of FcγRIIa/rs1801274 in the asymptomatic individuals when compared to that in the control group (p =0.03). Therefore, the results showed a high prevalence of asymptomatic individuals in Minas Gerais State, with a potential association between the presence of the G allele of FcγRIIa/rs1801274 and protection against symptomatic disease.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectDengue-
Palavras-chave: dc.subjectAsymptomatic patients-
Título: dc.titleHigh prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil.-
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