IL-33 in obesity : where do we go from here?

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Marcos Felipe Andrade de-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Autor(es): dc.creatorVieira, Etel Rocha-
Data de aceite: dc.date.accessioned2025-08-21T15:45:45Z-
Data de disponibilização: dc.date.available2025-08-21T15:45:45Z-
Data de envio: dc.date.issued2019-04-02-
Data de envio: dc.date.issued2019-04-02-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/10904-
Fonte completa do material: dc.identifierhttps://link.springer.com/article/10.1007%2Fs00011-019-01214-2-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023511-
Descrição: dc.descriptionIL-33 is a cytokine that belongs to the IL-1 family and is classically associated with type 2-like immune responses. In the adipose tissue, IL-33 is related to the beiging of adipocytes and to the maintenance of adipose tissue-resident immune cells, such as innate lymphoid cells 2, alternatively activated macrophages and regulatory T cells, which contribute to the maintenance of adipose tissue homeostasis. In the obese adipose tissue, the number of these cells is diminished, unlike the expression of IL-33, which is up-regulated. However, despite its increased expression, IL-33 is not able to maintain the homeostasis of the obese adipose tissue. IL-33 treatment, on the other hand, highly improves obesity-related inflammatory and metabolic alterations. The evidence that exogenous IL-33, but not adipose tissue-driven IL-33, regulates the inflammatory process in obesity leaves a gap in the understanding of IL-33 biology. Thus, in this review we discuss the potential mechanisms associated with the impaired action of IL-33 in obesity.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectType 2 innate lymphocyte-
Palavras-chave: dc.subjectST2; metabolism-
Palavras-chave: dc.subjectBeige adipocyte-
Palavras-chave: dc.subjectInflammation-
Título: dc.titleIL-33 in obesity : where do we go from here?-
Aparece nas coleções:Repositório Institucional - UFOP

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