Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBretas, Ana Carolina Oliveira-
Autor(es): dc.creatorSouza, Thiago Belarmino de-
Autor(es): dc.creatorBorelli, Beatriz-
Autor(es): dc.creatorJohan, Suzana-
Autor(es): dc.creatorAlves, Ricardo José-
Data de aceite: dc.date.accessioned2025-08-21T15:45:03Z-
Data de disponibilização: dc.date.available2025-08-21T15:45:03Z-
Data de envio: dc.date.issued2021-12-06-
Data de envio: dc.date.issued2021-12-06-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/14116-
Fonte completa do material: dc.identifierhttps://doi.org/10.1590/s2175-97902019000417652-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023240-
Descrição: dc.descriptionSystemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the development of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.-
Palavras-chave: dc.subjectβ-(1,3)-D-glucan synthase-
Palavras-chave: dc.subjectMolecular simplification-
Título: dc.titleSynthesis of novel papulacandin D analogs and evaluation of their antifungal potential.-
Aparece nas coleções:Repositório Institucional - UFOP

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