Schistosoma mansoni : egg-induced downregulation of hepatic stellate cell activation and fibrogenesis.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorAnthony, Barrie-
Autor(es): dc.creatorMathieson, William-
Autor(es): dc.creatorBorges, William de Castro-
Autor(es): dc.creatorAllen, Jeremy-
Data de aceite: dc.date.accessioned2025-08-21T15:45:03Z-
Data de disponibilização: dc.date.available2025-08-21T15:45:03Z-
Data de envio: dc.date.issued2015-03-16-
Data de envio: dc.date.issued2015-03-16-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4651-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.exppara.2009.12.009-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023236-
Descrição: dc.descriptionEggs of Schistosoma mansoni trapped in human liver can lead to fibrosis. Since liver fibrosis requires activation of hepatic stellate cells (HSC) from a quiescent to a myofibroblastic phenotype, we investigated the effects of S. mansoni eggs on this process using in vitro co-cultures with human HSC and evaluated established biomarkers for activation and fibrosis. HSC demonstrate significantly reduced expression of a-smooth muscle actin (p < 0.001), connective tissue growth factor (p < 0.01) and type I collagen (p < 0.001) but significantly increased expression of peroxisome proliferator-activated receptor-c (p < 0.01). Morphologically, HSC exhibited elongated fine cellular processes and reduced size, increased accumulation of lipid droplets and reduced expression and organization of a-smooth muscle actin and F-actin stress fibres. Additionally, schistosome eggs prevented the HSC fibrogenic response to exogenous transforming growth factor-b. In summary, schistosome eggs blocked fibrogenesis in HSC, a finding which may have implications for our understanding of the fibrotic pathology in S. mansoni infections.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3550940313825.-
Palavras-chave: dc.subjectSchistosomes-
Palavras-chave: dc.subjectLiver fibrosis-
Palavras-chave: dc.subjectRelative gene expression-
Palavras-chave: dc.subjectImmunocytochemistry-
Palavras-chave: dc.subjectTrematodes-
Título: dc.titleSchistosoma mansoni : egg-induced downregulation of hepatic stellate cell activation and fibrogenesis.-
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