Trypanocidal activity of flavanone derivatives.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorDiogo, Gabriela Maciel-
Autor(es): dc.creatorAndrade, Josimara Souza-
Autor(es): dc.creatorSales Júnior, Policarpo Ademar-
Autor(es): dc.creatorMurta, Silvane Maria Fonseca-
Autor(es): dc.creatorSantos, Viviane Martins Rebello dos-
Autor(es): dc.creatorTaylor, Jason Guy-
Data de aceite: dc.date.accessioned2025-08-21T15:44:40Z-
Data de disponibilização: dc.date.available2025-08-21T15:44:40Z-
Data de envio: dc.date.issued2020-06-15-
Data de envio: dc.date.issued2020-06-15-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/12347-
Fonte completa do material: dc.identifierhttps://www.mdpi.com/1420-3049/25/2/397-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/molecules25020397-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023068-
Descrição: dc.descriptionChagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase. Furthermore, strong side effects may result in discontinuation of this treatment. Faced with this situation, we report the synthesis and trypanocidal activity of 3-benzoyl-flavanones. Novel 3-benzoyl-flavanone derivatives were prepared in satisfactory yields in the 3-step synthetic procedure. According to recommended guidelines, the whole cell-based screening methodology was utilized that allowed for the simultaneous use of both parasite forms responsible for human infection. The majority of the tested compounds displayed promising anti-Trypanosoma cruzi activity and the most potent flavanone bearing a nitrofuran moiety was more potent than the reference drug, Benznidazole.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectChagas disease-
Palavras-chave: dc.subjectFlavonoids-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Palavras-chave: dc.subjectChromanones-
Palavras-chave: dc.subjectIn vitro-
Título: dc.titleTrypanocidal activity of flavanone derivatives.-
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