Nanostructured systems improve the antimicrobial potential of the essential oil from cymbopogon densiflorus leaves.

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Autor(es): dc.creatorSeibert, Janaína Brandão-
Autor(es): dc.creatorRosa, Juliana dos Santos-
Autor(es): dc.creatorAlmeida, Tamires Cunha-
Autor(es): dc.creatorAmparo, Tatiane Roquete-
Autor(es): dc.creatorRodrigues, Ivanildes Vasconcelos-
Autor(es): dc.creatorLanza, Juliane Sousa-
Autor(es): dc.creatorFrezard, Frederic Jean Georges-
Autor(es): dc.creatorSoares, Rodrigo Dian de Oliveira Aguiar-
Autor(es): dc.creatorTeixeira, Luiz Fernando de Medeiros-
Autor(es): dc.creatorSouza, Gustavo Henrique Bianco de-
Autor(es): dc.creatorVieira, Paula Melo de Abreu-
Autor(es): dc.creatorBarichello, José Mario-
Autor(es): dc.creatorSantos, Orlando David Henrique dos-
Data de aceite: dc.date.accessioned2025-08-21T15:44:31Z-
Data de disponibilização: dc.date.available2025-08-21T15:44:31Z-
Data de envio: dc.date.issued2020-04-27-
Data de envio: dc.date.issued2020-04-27-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/12107-
Fonte completa do material: dc.identifierhttps://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.8b00870-
Fonte completa do material: dc.identifierhttps://doi.org/10.1021/acs.jnatprod.8b00870-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1023003-
Descrição: dc.descriptionThe physicochemical characteristics of nanostructured suspensions are important prerequisites for the success of new drug development. This work aimed to develop nanometric systems containing Cymbopogon densiflorus leaf essential oil and to evaluate their antimicrobial activity. The essential oil was isolated by hydrodistillation from leaves and analyzed by GC-MS. The main constituents were found to be trans-p-mentha-2,8-dien-1-ol, cis-p-mentha2,8-dien-1-ol, trans-p-mentha-1(7),8-dien-2-ol, cis-piperitol, and cis-p-mentha-1(7),8-dien-2-ol. In silico prediction analysis suggested that this oil possesses antimicrobial potential and the main mechanism of action might be the peptidoglycan glycosyltransferase inhibition. Nanoemulsions were prepared by the phase inversion method, and liposomes were made by the film hydration method. Qualitative evaluation of the antimicrobial activity was performed by the diffusion disk assay with 24 microorganisms; all of them were found to be sensitive to the essential oil. Subsequently, this property was quantified by the serial microdilution technique, where the nanoformulations demonstrated improved activity in comparison with the free oil. Bactericidal action was tested by the propidium iodide method, which revealed that free essential oil and nanoemulsion increased cytoplasmic membrane permeability, while no difference was observed between negative control and liposome. These results were confirmed by images obtained using transmission electron microscopy. This study has shown an optimization in the antimicrobial activity of C. densiflorus essential oil by a nanoemulsion and a liposomal formulation of the active substances.-
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Idioma: dc.languageen-
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Título: dc.titleNanostructured systems improve the antimicrobial potential of the essential oil from cymbopogon densiflorus leaves.-
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