Are hemoglobin-derived peptides involved in the neuropsychiatric symptoms caused by SARS-CoV-2 infection?

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMendonça, Michelle Mendanha-
Autor(es): dc.creatorCruz, Kellen Rosa da-
Autor(es): dc.creatorSilva, Fernanda Cacilda dos Santos-
Autor(es): dc.creatorFontes, Marco Antônio Peliky-
Autor(es): dc.creatorXavier, Carlos Henrique-
Data de aceite: dc.date.accessioned2025-08-21T15:44:22Z-
Data de disponibilização: dc.date.available2025-08-21T15:44:22Z-
Data de envio: dc.date.issued2023-12-05-
Data de envio: dc.date.issued2023-12-05-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17903-
Fonte completa do material: dc.identifierhttps://doi.org/10.47626/1516-4446-2021-2339-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1022937-
Descrição: dc.descriptionFollow-up of patients affected by COVID-19 has unveiled remarkable findings. Among the several sequelae caused by SARS-CoV-2 viral infection, it is particularly noteworthy that patients are prone to developing depression, anxiety, cognitive disorders, and dementia as part of the post-COVID-19 syndrome. The multisystem aspects of this disease suggest that multiple mechanisms may converge towards post-infection clinical manifestations. The literature provides mechanistic hypotheses related to changes in classical neurotransmission evoked by SARS-CoV-2 infection; nonetheless, the interaction of peripherally originated classical and non-canonic peptidergic systems may play a putative role in this neuropathology. A wealth of robust findings shows that hemoglobin-derived peptides are able to control cognition, memory, anxiety, and depression through different mechanisms. Early erythrocytic death is found during COVID-19, which would cause excess production of hemoglobin-derived peptides. Following from this premise, the present review sheds light on a possible involvement of hemoglobin-derived molecules in the COVID-19 pathophysiology by fostering neuroscientific evidence that supports the contribution of this non-canonic peptidergic pathway. This rationale may broaden knowledge beyond the currently available data, motivating further studies in the field and paving ways for novel laboratory tests and clinical approaches.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectHemoglobin-
Palavras-chave: dc.subjectNeurotransmitters-
Palavras-chave: dc.subjectHemorphins-
Título: dc.titleAre hemoglobin-derived peptides involved in the neuropsychiatric symptoms caused by SARS-CoV-2 infection?-
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