Associating chitosan and microemulsion as a topical vehicle for the administration of herbal medicines.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Denise Aline de Jesus-
Autor(es): dc.creatorAmaral, Juliano Geraldo-
Autor(es): dc.creatorGarcia, Laryana Borges-
Autor(es): dc.creatorSantos, Milena Soares dos-
Autor(es): dc.creatorSilva, Lorena A. O.-
Autor(es): dc.creatorAlmeida, Maiara Prates de-
Autor(es): dc.creatorGomes, Angélica Ferraz-
Autor(es): dc.creatorBarros, Danielle Rocha Pinho-
Autor(es): dc.creatorLopes, Norberto Peporine-
Autor(es): dc.creatorPereira, Gislaine Ribeiro-
Autor(es): dc.creatorSantos, Orlando David Henrique dos-
Autor(es): dc.creatorRuela, André Luís Morais-
Data de aceite: dc.date.accessioned2025-08-21T15:43:59Z-
Data de disponibilização: dc.date.available2025-08-21T15:43:59Z-
Data de envio: dc.date.issued2021-12-06-
Data de envio: dc.date.issued2021-12-06-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/14107-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/abs/pii/S0144861720316556-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.carbpol.2020.117482-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1022787-
Descrição: dc.descriptionA viscous solution of low molecular weight chitosan (CH) at 5% w/v (10.2 kDa, 75 % deacetylated, 1451 cP at 25 ◦C) was associated with a microemulsion (ME) that undergoes a phase transition after water absorption in situ (≈28 % w/w), forming a more viscous liquid crystal, which was potentially evaluated as a topical vehicle. The ME was selected from a phase diagram, selecting a composition based on Tween® 80 (52 %), myristate isopropyl (28 %), and the aqueous phase (water and polyethylene glycol 400, 60:40 w/w) (20 %), which was after replaced by CH and herbal medicines (HM). HM are alternatives to treat candidiasis, and Stryphnodendron adstringens shell extract, characterized by molecular networking, and Melaleuca alternifolia Chell essential oil (46 % of terpinen-4- ol), showed in vitro activity against Candida albicans. Associating CH in ME improved the mechanical properties of the topical formulation, as adhesiveness, which is an advantageous feature for the topical treatment of vul vovaginal candidiasis.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectLiquid crystal-
Palavras-chave: dc.subjectAdhesiveness-
Palavras-chave: dc.subjectRheology-
Palavras-chave: dc.subjectMolecular networking-
Título: dc.titleAssociating chitosan and microemulsion as a topical vehicle for the administration of herbal medicines.-
Aparece nas coleções:Repositório Institucional - UFOP

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