In vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorAntunes, Amanda dos Santos-
Autor(es): dc.creatorGouveia, Ana Paula Araújo-
Autor(es): dc.creatorDiogo, Gabriela Maciel-
Autor(es): dc.creatorTaylor, Jason Guy-
Autor(es): dc.creatorSousa, Lucas Resende Dutra-
Autor(es): dc.creatorAmparo, Tatiane Roquete-
Autor(es): dc.creatorPerasoli, Fernanda Barçante-
Autor(es): dc.creatorSantos, Orlando David Henrique dos-
Autor(es): dc.creatorCazati, Thiago-
Autor(es): dc.creatorVieira, Paula Melo de Abreu-
Autor(es): dc.creatorPenido, Ricardo Gonçalves-
Autor(es): dc.creatorSantos, Viviane Martins Rebello dos-
Data de aceite: dc.date.accessioned2025-08-21T15:43:55Z-
Data de disponibilização: dc.date.available2025-08-21T15:43:55Z-
Data de envio: dc.date.issued2021-12-20-
Data de envio: dc.date.issued2021-12-20-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/14284-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.21577/0103-5053.20210072-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1022751-
Descrição: dc.descriptionChromone derivatives exhibiting high absorbance values in the UVA/UVB region were synthesized, and their photoprotective properties were evaluated. Chromones were prepared according to known literature procedures and characterized by high resolution mass spectrometry, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. The in vitro solar protection factor (SPF) was determined by the Mansur method and cytotoxicity was evaluated using the sulforhodamine B assay. Two of the chromones synthesized demonstrated suitable SPF values and displayed no cytotoxic effect towards MRC-5 human fibroblasts at the tested concentrations, indicating great potential for future in vivo assays and clinical trials. Finally, the lead compound was incorporated into a nanoemulsion. Nanoemulsions showed high droplet size homogeneity and excellent stability. Chromones bearing methoxy substituents were found to be the most promising compounds with ideal photoprotective properties desirable for utilization and incorporation in sunscreen formulations.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.-
Palavras-chave: dc.subjectMansur-
Palavras-chave: dc.subjectOrganic UV filters-
Palavras-chave: dc.subjectCytotoxicity-
Título: dc.titleIn vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative.-
Aparece nas coleções:Repositório Institucional - UFOP

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