Novel Fe3O4 nanoparticles with bioactive glass–naproxen coating : synthesis, characterization, and in vitro evaluation of bioactivity.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorValverde, Thalita Marcolan-
Autor(es): dc.creatorSantos, Viviane Martins Rebello dos-
Autor(es): dc.creatorViana, Pedro Igor Macário-
Autor(es): dc.creatorCosta, Guilherme Mattos Jardim-
Autor(es): dc.creatorGoes, Alfredo Miranda de-
Autor(es): dc.creatorSousa, Lucas Resende Dutra-
Autor(es): dc.creatorXavier, Viviane Flores-
Autor(es): dc.creatorVieira, Paula Melo de Abreu-
Autor(es): dc.creatorSilva, Daniel de Lima-
Autor(es): dc.creatorDomingues, Rosana Zacarias-
Autor(es): dc.creatorFerreira, José Maria da Fonte-
Autor(es): dc.creatorAndrade, Ângela Leão-
Data de aceite: dc.date.accessioned2025-08-21T15:43:50Z-
Data de disponibilização: dc.date.available2025-08-21T15:43:50Z-
Data de envio: dc.date.issued2025-03-13-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19927-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/ijms25084270-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1022717-
Descrição: dc.descriptionImmune response to biomaterials, which is intimately related to their surface properties, can produce chronic inflammation and fibrosis, leading to implant failure. This study investigated the development of magnetic nanoparticles coated with silica and incorporating the anti-inflammatory drug naproxen, aimed at multifunctional biomedical applications. The synthesized nanoparticles were characterized using various techniques that confirmed the presence of magnetite and the formation of a silica-rich bioactive glass (BG) layer. In vitro studies demonstrated that the nanoparticles exhibited bioactive properties, forming an apatite surface layer when immersed in simulated body fluid, and biocompatibility with bone cells, with good viability and alkaline phosphatase activity. Naproxen, either free or encapsulated, reduced nitric oxide production, an inflammatory marker, while the BG coating alone did not show anti-inflammatory effects in this study. Overall, the magnetic nanoparticles coated with BG and naproxen showed promise for biomedical applications, especially anti-inflammatory activity in macrophages and in the bone field, due to their biocompatibility, bioactivity, and osteogenic potential.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.-
Palavras-chave: dc.subjectMagnetic nanoparticles-
Palavras-chave: dc.subjectSilica-
Palavras-chave: dc.subjectBiocompatibility-
Título: dc.titleNovel Fe3O4 nanoparticles with bioactive glass–naproxen coating : synthesis, characterization, and in vitro evaluation of bioactivity.-
Aparece nas coleções:Repositório Institucional - UFOP

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