Development of a topical treatment for tegumentary leishmaniasis using 8-hydroxyquinoline.

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Autor(es): dc.creatorRibeiro, Naianda Rezende-
Autor(es): dc.creatorSantos, Lucas Magno Oliveira-
Autor(es): dc.creatorCosta, Scarleth Silva-
Autor(es): dc.creatorMyasaki, Carolina Kei-
Autor(es): dc.creatorLage, Daniela Pagliara-
Autor(es): dc.creatorMartins, Vivian Tamietti-
Autor(es): dc.creatorBrito, Rory Cristiane Fortes de-
Autor(es): dc.creatorFreire, Larissa Chaves-
Autor(es): dc.creatorCarvalho, Ana Maria Ravena Severino-
Autor(es): dc.creatorBrigido, Bryan Victor Serafim-
Autor(es): dc.creatorAlves, Ricardo José-
Autor(es): dc.creatorCoelho, Eduardo Antônio Ferraz-
Autor(es): dc.creatorRoatt, Bruno Mendes-
Autor(es): dc.creatorSouza, Daniel Menezes-
Autor(es): dc.creatorDuarte, Mariana Costa-
Data de aceite: dc.date.accessioned2025-08-21T15:43:48Z-
Data de disponibilização: dc.date.available2025-08-21T15:43:48Z-
Data de envio: dc.date.issued2025-02-21-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19770-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0939641124001322-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.ejpb.2024.114306-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1022701-
Descrição: dc.descriptionIn the context of neglected diseases, tegumentary leishmaniasis (TL) presents an emerging and re-emerging character in the national territory and in the world. The treatment of TL has limitations, such as intravenous administration route, high toxicity, and high treatment costs. Thus, several researchers work on new therapeutic strategies to improve the effectiveness of the treatment of leishmaniasis. In this light, the present study used a topical formulation, containing 8-hydroquinoline (8-HQN), for the treatment of Balb/c mice infected with L. amazonensis. After the treatment, the mean diameter of the lesion was measured, as well as the parasite load in organs and immunological parameters associated with the treatment. The results showed that the animals treated with 8-HQN 5%, when compared to controls, showed a reduction in the mean diameter of the lesion and in the parasite load. The animals treated with the ointment showed a type 1 cellular immune response profile associated with the production of cytokines such as INF-γ and TNF-α. In addition, the treatment did not demonstrate toxicity to mice. Therefore, the topical formulation containing 8-HQN 5% is a promising candidate in the topical treatment and could be considered, in the future, as an alternative for the treatment of TL.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectLeishmaniasis-
Palavras-chave: dc.subjectLeishmania amazonensis-
Palavras-chave: dc.subjectTreatment-
Palavras-chave: dc.subjectTopical treatment-
Palavras-chave: dc.subject8-Hydroxiquinoline-
Título: dc.titleDevelopment of a topical treatment for tegumentary leishmaniasis using 8-hydroxyquinoline.-
Aparece nas coleções:Repositório Institucional - UFOP

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