Heating capacity and biocompatibility of hybrid nanoparticles for magnetic hyperthermia treatment.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorGomes, Aline Alexandrina-
Autor(es): dc.creatorValverde, Thalita Marcolan-
Autor(es): dc.creatorMachado, Vagner de Oliveira-
Autor(es): dc.creatorSilva, Emanueli do Nascimento da-
Autor(es): dc.creatorFagundes, Daniele Alves-
Autor(es): dc.creatorOliveira, Fernanda de Paula-
Autor(es): dc.creatorFreitas, Erico Tadeu Fraga-
Autor(es): dc.creatorArdisson, José Domingos-
Autor(es): dc.creatorFerreira, José Maria da Fonte-
Autor(es): dc.creatorOliveira, Junnia Alvarenga de Carvalho-
Autor(es): dc.creatorGomes, Eliza Rocha-
Autor(es): dc.creatorRodrigues, Caio Fabrini-
Autor(es): dc.creatorGoes, Alfredo Miranda de-
Autor(es): dc.creatorDomingues, Rosana Zacarias-
Autor(es): dc.creatorAndrade, Ângela Leão-
Data de aceite: dc.date.accessioned2025-08-21T15:43:37Z-
Data de disponibilização: dc.date.available2025-08-21T15:43:37Z-
Data de envio: dc.date.issued2025-03-21-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/20005-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/ijms25010493-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1022627-
Descrição: dc.descriptionCancer is one of the deadliest diseases worldwide and has been responsible for millions of deaths. However, developing a satisfactory smart multifunctional material combining different strategies to kill cancer cells poses a challenge. This work aims at filling this gap by developing a composite material for cancer treatment through hyperthermia and drug release. With this purpose, magnetic nanoparticles were coated with a polymer matrix consisting of poly (L-co-D,L lactic acid- co-trimethylene carbonate) and a poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymer. High-resolution transmission electron microscopy and selected area electron diffraction confirmed magnetite to be the only iron oxide in the sample. Cytotoxicity and heat release assays on the hybrid nanoparticles were performed here for the first time. The heat induction results indicate that these new magnetic hybrid nanoparticles are capable of increasing the temperature by more than 5 ◦C, the minimal temperature rise required for being effectively used in hyperthermia treatments. The biocompatibility assays conducted under different concentrations, in the presence and in the absence of an external alternating current magnetic field, did not reveal any cytotoxicity. Therefore, the overall results indicate that the investigated hybrid nanoparticles have a great potential to be used as carrier systems for cancer treatment by hyperthermia.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.-
Palavras-chave: dc.subjectHybrid nanoparticles-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectHyperthermia-
Título: dc.titleHeating capacity and biocompatibility of hybrid nanoparticles for magnetic hyperthermia treatment.-
Aparece nas coleções:Repositório Institucional - UFOP

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